Meekins Jessica, Cino-Ozuna Ada G
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
JFMS Open Rep. 2018 Nov 21;4(2):2055116918813242. doi: 10.1177/2055116918813242. eCollection 2018 Jul-Dec.
A 5-month-old male intact domestic shorthair (DSH) cat (cat 1), a 1-year-old male neutered DSH cat (cat 2) and a 1.5-year-old female spayed DSH cat (cat 3) were submitted for gross necropsy after acute death, with the clinical suspicion of cytauxzoonosis. All three cats displayed signs of rapidly progressive clinical deterioration, including lethargy, anorexia, and hyper- or hypothermia. Cat 1 was euthanized owing to the grave prognosis for survival, whereas cats 2 and 3 were found dead 1-4 days after the onset of clinical signs. Remains were submitted to the Kansas State University Veterinary Diagnostic Laboratory for gross necropsy. In all three cats, general examination findings included icterus of the mucous membranes, multifocal pulmonary parenchymal hemorrhages, and splenic reddening and enlargement. Histologic examination revealed macrophages laden with protozoal schizonts diffusely distributed within blood vessels and vascular spaces of all affected organs, including the blood vessels of the uveal tract. The ciliary body within the anterior uveal tract was most affected.
This is the first description of cytauxzoonosis affecting the eyes of infected cats. This report confirms involvement of ocular blood vessels similar to the classic lesions of the lungs, spleen and liver. In cats presenting with a history and clinical findings suggestive of cytauxzoonosis, complete ophthalmic examination is indicated to confirm or rule out ocular involvement.
一只5个月大的未绝育家养短毛（DSH）雄性猫（猫1）、一只1岁的已绝育DSH雄性猫（猫2）和一只1.5岁的已绝育DSH雌性猫（猫3）在急性死亡后被提交进行大体尸检，临床怀疑为嗜吞噬细胞无形体病。所有三只猫均表现出临床迅速恶化的迹象，包括嗜睡、厌食和体温过高或过低。由于生存预后不佳，猫1被实施安乐死，而猫2和猫3在出现临床症状后1 - 4天被发现死亡。遗体被提交至堪萨斯州立大学兽医诊断实验室进行大体尸检。在所有三只猫中，一般检查结果包括黏膜黄疸、多灶性肺实质出血以及脾脏发红和肿大。组织学检查显示，充满原生动物裂殖体的巨噬细胞弥漫分布于所有受影响器官的血管和血管间隙内，包括葡萄膜的血管。前葡萄膜内的睫状体受影响最为严重。
这是关于嗜吞噬细胞无形体病感染猫眼部的首次描述。本报告证实眼部血管受累情况与肺、脾和肝的典型病变相似。对于有嗜吞噬细胞无形体病病史和临床症状的猫，建议进行全面的眼科检查以确认或排除眼部受累情况。
