Department of Neurology, Biomedical Sciences Graduate Program, and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California.
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Aging Cell. 2019 Feb;18(1):e12871. doi: 10.1111/acel.12871. Epub 2018 Dec 17.
Female longevity is observed in humans and much of the animal kingdom, but its causes remain elusive. Using a genetic manipulation that generates XX and XY mice, each with either ovaries or testes, we show that the female XX sex chromosome complement increases survival during aging in male and female mice. In combination with ovaries, it also extends lifespan. Understanding causes of sex-based differences in aging could lead to new pathways to counter age-induced decline in both sexes.
女性长寿现象存在于人类和大部分动物界，但具体原因仍难以捉摸。本研究采用遗传操作手段，构建了既有卵巢又有睾丸的 XX 和 XY 雌雄同体小鼠，结果显示 XX 性染色体在雌雄小鼠衰老过程中提高了存活率。XX 性染色体与卵巢联合作用还延长了寿命。探究性别差异在衰老过程中的作用机制可能为两性衰老相关疾病的防治提供新的思路。
