健康男性短期β-肾上腺素能阻滞剂治疗期间的血清和尿磷水平

Serum and urine phosphate during short-term beta-adrenergic blockade in healthy men.

作者信息

Lindsay R, Ramsay L E, Hettiarrachchi J, Davies D L, Beastall G H

出版信息

Clin Pharmacol Ther. 1978 Dec;24(6):650-3. doi: 10.1002/cpt1978246650.

DOI:10.1002/cpt1978246650

Abstract

Treatment of 6 healthy adult men with a beta-blocker, timolol, resulted in a rise in serum phosphate which was maintained for the 5 days of therapy. This rise was accompanied by a transient fall in urine phosphate and a rise in the tubular maximum for phosphate reabsorption per unit glomerular filtration rate (TmPO4/GFR). No change in circulating parathyroid hormone or growth hormone could be demonstrated.

摘要

对6名健康成年男性使用β受体阻滞剂噻吗洛尔进行治疗，结果导致血清磷酸盐升高，且在治疗的5天内一直维持。这种升高伴随着尿磷酸盐的短暂下降以及单位肾小球滤过率的磷酸盐重吸收最大转运率（TmPO4/GFR）升高。未发现循环甲状旁腺激素或生长激素有变化。