Zhou Diana, Zhao Yinghong, Hook Michael, Zhao Wenyuan, Starlard-Davenport Athena, Cook Melloni N, Jones Byron C, Hamre Kristin M, Lu Lu
Department of Genetics, Genomics and Informatics, The University of Tennessee Health Science Center, Memphis, TN, United States.
Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China.
Front Genet. 2018 Dec 4;9:602. doi: 10.3389/fgene.2018.00602. eCollection 2018.
Coenzyme Q (CoQ) is a well-studied molecule, present in every cell membrane in the body, best known for its roles as a mitochondrial electron transporter and a potent membrane anti-oxidant. Much of the previous work was done in yeast and more recent work has suggested that CoQ may have additional roles prompting calls for a re-assessment of its role using systems in mammals. Here we investigated the putative role of Coenzyme Q in ethanol-induced effects using BXD RI mice. We examined hippocampal expression of in saline controls and after an acute ethanol treatment, noting enriched biologic processes and pathways following ethanol administration. We also identified 45 ethanol-related phenotypes that were significantly correlated with expression, including six phenotypes related to conditioned taste aversion and ethanol preference. This analysis highlights the need for further investigation of and related genes as well as previously unrecognized roles that it may play in the hippocampus.
辅酶Q（CoQ）是一种经过充分研究的分子，存在于人体的每个细胞膜中，最广为人知的作用是作为线粒体电子转运体和一种强大的膜抗氧化剂。以前的许多研究是在酵母中进行的，最近的研究表明，辅酶Q可能具有其他作用，这促使人们呼吁使用哺乳动物系统重新评估其作用。在这里，我们使用BXD RI小鼠研究了辅酶Q在乙醇诱导效应中的假定作用。我们检查了生理盐水对照组和急性乙醇处理后海马体中的表达情况，记录了乙醇给药后富集的生物学过程和通路。我们还确定了45种与乙醇相关的表型，这些表型与表达显著相关，包括六种与条件性味觉厌恶和乙醇偏好相关的表型。该分析强调了进一步研究辅酶Q及其相关基因以及它可能在海马体中发挥的先前未被认识的作用的必要性。
