Mathieu D, Jacques L, Auer J, Bizzini B
Service de Microbiologie, Hôpital Paul Brousse, Villejuif, France.
Biomed Pharmacother. 1988;42(4):271-7.
A model of infection by E. coli 022 of the lower urinary tract in the rat is described. The infection is characterized by the presence in the urine of a large number of E. coli (10(5)-10(7) bacteria per ml). There is pus formation in the urine. A few infected rats also exhibited prostate hypertrophy and the presence of ACB could be detected in some of the latter group. Treatment of the infected rats by the C. granulosum-derived immunomodulator P40, injected intravenously either as a single dose of 1 mg per rat 1 day after infection or as 2 fractionated doses of 0.5 mg 1 day and 3 days after infection resulted in sterilization of a significant number of urines. The interest of fractionating the dose of P40 is to reduce the incidence of prostate hypertrophy formation. Comparable results were obtained when P40 was given preventively to the rats either as a single dose 7 days before infection or as 2 fractionated doses 7 days and 1 day before infection. The association of a single preventive dose of 1 mg of P40 given 7 days before infection by administering a suspension of heat-killed E. coli 022, as a specific antigen, 1 day after infection permitted the sterilization of urines in all infected rats and prostate hypertrophy formation did not occur.
本文描述了大鼠下尿路大肠杆菌O22感染模型。该感染的特征是尿液中存在大量大肠杆菌（每毫升尿液中有10⁵ - 10⁷个细菌），尿液中有脓液形成。少数感染大鼠还出现前列腺肥大，且在后者的部分大鼠中可检测到抗酸杆菌（ACB）的存在。用源自颗粒丙酸杆菌的免疫调节剂P40对感染大鼠进行治疗，在感染后1天以每只大鼠1毫克的单剂量静脉注射，或在感染后1天和3天以0.5毫克的2个分次剂量静脉注射，可使大量尿液无菌。将P40剂量分次使用的目的是降低前列腺肥大形成的发生率。当在感染前7天给大鼠预防性给予P40时，无论是以单剂量还是在感染前7天和1天以2个分次剂量给药，都可获得类似结果。在感染前7天给予1毫克P40单剂量预防，在感染后1天给予热灭活大肠杆菌O22悬液作为特异性抗原，可使所有感染大鼠的尿液无菌，且未出现前列腺肥大。
