Frierson H F, Deutsch B D, Levine P A
Department of Pathology, University of Virginia Medical Center, Charlottesville 22908.
Hum Pathol. 1988 Dec;19(12):1397-402. doi: 10.1016/s0046-8177(88)80232-6.
The clinicopathologic features of 32 cutaneous squamous cell carcinomas of the head and neck in 12 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma were examined to determine the frequency of clinically aggressive and histologically poorly differentiated carcinomas in this group of patients. Two thirds of the neoplasms were multiple and 56% were high grade (grade 3 or 4). One of the 12 patients had recurrent carcinoma, two patients had recurrent and metastatic disease, and two patients had metastatic tumor without recurrence. Two patients died of tumor, one patient is alive with extensive recurrent and metastatic disease, and one patient died of an uncertain type of carcinoma. An additional patient with squamous cell carcinoma of the face died of cutaneous squamous cell carcinoma that arose on the chest. This study shows that cutaneous squamous cell carcinomas of the head and neck in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma are often high grade and have the potential for recurrence and metastasis.
对12例慢性淋巴细胞白血病/小淋巴细胞淋巴瘤患者的32例头颈部皮肤鳞状细胞癌的临床病理特征进行了检查，以确定该组患者中临床侵袭性和组织学低分化癌的发生率。三分之二的肿瘤为多发，56%为高级别（3级或4级）。12例患者中有1例发生复发性癌，2例有复发和转移性疾病，2例有转移性肿瘤但无复发。2例患者死于肿瘤，1例患者虽有广泛复发和转移性疾病但仍存活，1例患者死于类型不明的癌。另外1例面部鳞状细胞癌患者死于胸部发生的皮肤鳞状细胞癌。这项研究表明，慢性淋巴细胞白血病/小淋巴细胞淋巴瘤患者的头颈部皮肤鳞状细胞癌通常为高级别，具有复发和转移的可能性。
