芬兰 774 例患者中复发性和转移性皮肤鳞状细胞癌的队列研究。
Recurrent and Metastatic Cutaneous Squamous Cell Carcinomas in a Cohort of 774 Patients in Finland.
机构信息
Department of Dermatology and Allergology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, FIN-33521 Tampere, Finland. E-mail:
出版信息
Acta Derm Venereol. 2020 Apr 21;100(8):adv00121. doi: 10.2340/00015555-3479.
Recognising patients with high risk cutaneous squamous cell carcinomas is essential in planning effective monitoring. The aim of this study was to determine the rate of local recurrences and metastases of cutaneous squamous cell carcinomas in a previously defined patient cohort in Finland. Pathology database search was performed to identify cutaneous squamous cell carcinoma patients and their medical records were reviewed. The cohort consisted of 774 patients with 1,131 cutaneous squamous cell carcinoma tumours. Overall, 4.2% (48/1,131) of the tumours were metastatic and 2.2% (25/1,131) had a local recurrence. Three of the metastatic tumours and 8 of the recurrent tumours had an invasion depth of ≤ 2 mm. The majority of metastases (28/48; 58%) were found within 3 months of the diagnosis of cutaneous squamous cell carcinoma. In conclusion, our study demonstrated recurrences and metastases even in the case of thin cutaneous squamous cell carcinomas and in high-risk cases close monitoring should be organised during the first years after diagnosis.
识别患有高危皮肤鳞状细胞癌的患者对于规划有效的监测至关重要。本研究的目的是确定芬兰既往定义的患者队列中皮肤鳞状细胞癌的局部复发和转移率。通过病理数据库检索识别皮肤鳞状细胞癌患者，并对其病历进行回顾性分析。该队列包括 774 名患者，共 1131 个皮肤鳞状细胞癌肿瘤。总体而言，4.2%（48/1131）的肿瘤发生转移，2.2%（25/1131）发生局部复发。3 个转移性肿瘤和 8 个复发性肿瘤的浸润深度≤2mm。大多数转移（28/48；58%）在诊断为皮肤鳞状细胞癌后的 3 个月内发现。总之，本研究表明，即使是在皮肤鳞状细胞癌较薄的情况下，也会发生复发和转移，对于高危病例，应在诊断后的最初几年内组织密切监测。
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