Blagojevic Iva Perovic, Eror Tatjana, Pelivanovic Jovana, Jelic Svetlana, Kotur-Stevuljevic Jelena, Ignjatovic Svetlana
Department of Laboratory Diagnostic, Clinical Hospital Center »Dr Dragisa Misovic - Dedinje«, Belgrade, Serbia.
Clinic of Internal Medicine, Clinical Hospital Center »Dr Dragisa Misovic - Dedinje«, Belgrade, Serbia.
J Med Biochem. 2017 Jul 14;36(3):259-269. doi: 10.1515/jomb-2017-0020. eCollection 2017 Sep.
Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk.
Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated.
Significantly higher CVRS values (p<0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p<0.001, p<0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLD indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC>0.8) in identifying patients with increased cardiovascular risk (CVR).
Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.
多囊卵巢综合征（PCOS）与生殖和代谢异常有关。本研究的目的是分析PCOS患者患心血管疾病（CVD）的风险，确定个体风险因素并评估其预测风险的能力。
将54名患有PCOS的年轻女性（22名肥胖和32名正常体重）与46名相应的对照组（17名肥胖和29名正常体重）进行比较。测量人体测量参数、血脂状态参数、炎症标志物、血糖、转氨酶、性激素和垂体前叶激素、性激素结合球蛋白（SHBG）和雄激素的浓度。计算心血管风险评分（CVRS）、识别非酒精性脂肪性肝病（NAFLD）的指标和中心性肥胖指数（ICO）。
与正常体重对照组和正常体重PCOS组相比，肥胖PCOS女性的CVRS值显著更高（p<0.05）。CVRS较高的女性的人体测量参数、血脂状态参数和纤维蛋白原（p<0.001，p<0.01）更高。所有PCOS女性中最显著的CVRS预测因素是SHBG、雄烯二酮、促卵泡激素（FSH）和硫酸脱氢表雄酮（DHEAS）。ICO和所有NAFLD指标与CVRS呈显著正相关，由这些指标组成的模型在识别心血管风险（CVR）增加的患者方面具有良好的诊断准确性（AUC>0.8）。
肥胖比单独的PCOS更易发生CVD。人体测量参数、血脂参数、纤维蛋白原、NAFLD指标和ICO会增加PCOS女性的CVR。对于预测PCOS患者的CVR，我们建议结合NAFLD指标和ICO。
