Maity Priyanka, Sengupta Moumita, Jain Kavita, Chaudhuri Shubhamitra, Chatterjee Uttara, Datta Chhanda, Chatterjee Sandip
Department of Pathology, IPGME&R, Kolkata, India.
Department of Neurosurgery, BIN, Kolkata, India.
Diagn Cytopathol. 2019 May;47(5):428-433. doi: 10.1002/dc.24132. Epub 2018 Dec 19.
Role of squash cytology in intraoperative diagnosis of central nervous system lesions has been well established. Intraoperative diagnosis is especially important in paediatric CNS lesions as decision regarding gross total resection or near total resection or subtotal resection is crucial and radiotherapy and chemotherapy are best avoided in this age group. The aim of this study was to evaluate the utility of squash cytology of CNS lesions in paediatric age group and to assess its diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value.
A prospective study was conducted on 42 paediatric patients with clinico-radiologically diagnosed CNS lesions. Intraoperative squash smears were stained with haematoxylin and eosin (H&E) stain. Diagnosis made subsequently on paraffin sections was taken as gold standard.
The overall diagnostic accuracy of intraoperative squash cytology of CNS lesions in paediatric age group was 73.80%. The sensitivity, specificity, positive predictive value and negative predictive value of this modality were 92.31%, 87.50%, 96.00% and 77.78%, respectively.
The spectrum of CNS lesions in paediatric age group is different from that in adults. Though the sensitivity and specificity of squash cytology in paediatric tumours are less than that of adults, it is an important tool for intraoperative diagnosis that guides regarding the extent of resection.
squash细胞学在中枢神经系统病变术中诊断中的作用已得到充分确立。术中诊断在儿童中枢神经系统病变中尤为重要，因为关于肿瘤全切、近全切或次全切的决策至关重要，且该年龄组最好避免放疗和化疗。本研究的目的是评估squash细胞学在儿童年龄组中枢神经系统病变中的实用性，并评估其诊断准确性、敏感性、特异性、阳性预测值和阴性预测值。
对42例临床放射学诊断为中枢神经系统病变的儿科患者进行了一项前瞻性研究。术中squash涂片用苏木精和伊红（H&E）染色。随后在石蜡切片上做出的诊断被视为金标准。
儿童年龄组中枢神经系统病变术中squash细胞学的总体诊断准确性为73.80%。该方法的敏感性、特异性、阳性预测值和阴性预测值分别为92.31%、87.50%、96.00%和77.78%。
儿童年龄组中枢神经系统病变的范围与成人不同。虽然squash细胞学在儿童肿瘤中的敏感性和特异性低于成人，但它是术中诊断的重要工具，可指导手术切除范围。
