Inanc Yusuf, Inanc Yılmaz
Ann Ital Chir. 2018;89:367-373.
The aim of the study was to investigate the effect of neutrophil lymphocyte (NLR) and platelet lymphocyte ratio (PLR) on prognosis in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy.
MATERIAL-METHOD: A retrospective study was made of the data of 56 patients aged 20-80 years who were diagnosed with AIS and underwent mechanical thrombectomy. Thrombolysis in Brain Ischemia (TIBI) status was evaluated with transcranial Doppler after treatment. The National Institutes of Health Stroke Scale (NIHHS) and modified Rankin scale (mRS) were used to indicate neurological and functional deficits.
No difference was determined in the NLR and PLR between patients with or without middle cerebral artery (MCA) occlusion, T and basilar occlusion. These ratios were also no different between the groups with different degrees of recanalization. Platelet lymphocyte ratio was lower in patients with a dramatic improvement at the 24th hour (p=0.046). Neutrophil lymphocyte ratio was higher in patients with symptomatic hemorrhage (p=0.046).
Although no relationship with outcome has yet been shown, the association with hemorrhagic change and the recovery parameters at the 24th hour may enable NLR and PLR to be used as significant prognostic factors in patients with acute ischemic stroke undergoing mechanical thrombectomy. Further studies are needed.
Ischemia, Mechanical thrombectomy, Neutrophil lymphocyte ratio, Platelet lymphocyte ratio, Stroke.
本研究旨在探讨中性粒细胞淋巴细胞比值（NLR）和血小板淋巴细胞比值（PLR）对接受机械取栓治疗的急性缺血性卒中（AIS）患者预后的影响。
对56例年龄在20至80岁之间、诊断为AIS并接受机械取栓治疗的患者的数据进行回顾性研究。治疗后采用经颅多普勒评估脑缺血溶栓（TIBI）状态。使用美国国立卫生研究院卒中量表（NIHHS）和改良Rankin量表（mRS）来评估神经功能缺损和功能障碍情况。
大脑中动脉（MCA）闭塞组与非闭塞组、T型闭塞组与基底动脉闭塞组之间的NLR和PLR无差异。不同再通程度组之间这些比值也无差异。24小时时有显著改善的患者血小板淋巴细胞比值较低（p=0.046）。有症状性出血的患者中性粒细胞淋巴细胞比值较高（p=0.046）。
尽管尚未显示与预后有相关性，但与出血性改变以及24小时时的恢复参数之间的关联可能使NLR和PLR能够作为接受机械取栓治疗的急性缺血性卒中患者的重要预后因素。还需要进一步研究。
缺血；机械取栓；中性粒细胞淋巴细胞比值；血小板淋巴细胞比值；卒中
