锌介导的叔醇草酸盐的碎裂反应，可实现烷基化和芳基化的季碳中心的构建。
Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers.
机构信息
School of Materials Science and Engineering, Center for Supramolecular Chemistry and Catalysis and Department of Chemistry , Shanghai University , Shanghai , China 200444.
出版信息
J Am Chem Soc. 2019 Jan 16;141(2):820-824. doi: 10.1021/jacs.8b12801. Epub 2018 Dec 31.
Zn-mediated reduction of readily accessible dialkyl oxalates derived from tertiary alcohols provides an efficient approach to C-O bond fragmentation and alkyl radical formation. With MgCl as the indispensable additive and Ni as the promoter, trapping the radical with activated alkenes and aryl-Ni intermediates allows for the generation of alkylated and arylated all-carbon quaternary centers.
Zn 介导的易于获得的叔醇衍生的二烷基丙二酸酯的还原提供了一种有效的 C-O 键断裂和烷基自由基形成的方法。以 MgCl 作为不可或缺的添加剂，Ni 作为促进剂，用活化的烯烃和芳基-Ni 中间体捕获自由基，可以生成烷基化和芳基化的全碳季碳中心。
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