Endo Yushiro, Koga Tomohiro, Eguchi Mizuna, Okamoto Momoko, Tsuji Sosuke, Takatani Ayuko, Shimizu Toshimasa, Sumiyoshi Remi, Igawa Takashi, Kawashiri Shin-Ya, Iwamoto Naoki, Ichinose Kunihiro, Tamai Mami, Nakamura Hideki, Origuchi Tomoki, Kawakami Atsushi
Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Medicine (Baltimore). 2018 Dec;97(51):e13295. doi: 10.1097/MD.0000000000013295.
Power Doppler ultrasonography (PDUS) in musculoskeletal ultrasound (MSUS) is a sensitive and reliable method for the assessment of rheumatoid arthritis (RA). The association between ultrasound-detectable forefoot bursae and the development of RA has gained attention. However, a few studies have evaluated the utility of PDUS for examining forefoot bursae in early RA. We report the case of an RA patient who developed reduced foot mobility and had detectable intermetatarsal bursitis with remarkable power Doppler (PD) signals in MSUS at the onset of RA.
A 40-year-old Japanese woman diagnosed with palindromic rheumatism visited our department due to sustained forefoot pain and difficulty walking. The levels of both rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) were high. She had opening toes with swelling in metatarsophalangeal (MTP) joints. PDUS showed intermetatarsal bursitis with mild MTP synovitis.
We diagnosed RA by comprehensive judgment based on the 2010 American College of Rheumatology and European League Against Rheumatism classification criteria for RA.
We administered 6.0 mg/wk of methotrexate (MTX) and 2.0 mg/d of prednisolone (PSL) followed by an increase of MTX to 10 mg/wk.
After those treatments, the patient's symptoms showed improvement. As of this writing, the patient's remission has been maintained for >2 months.
Her case suggests that PDUS is useful for the detection of forefoot bursitis, and the detection of forefoot bursitis by PDUS may provide the opportunity to make an early diagnosis of RA.
肌肉骨骼超声(MSUS)中的能量多普勒超声检查(PDUS)是评估类风湿关节炎(RA)的一种敏感且可靠的方法。超声可检测到的前足滑囊与RA的发展之间的关联已受到关注。然而,很少有研究评估PDUS在早期RA中检查前足滑囊的效用。我们报告了1例RA患者,该患者在RA发病时出现足部活动度降低,并且在MSUS中可检测到跖间滑囊炎并伴有显著的能量多普勒(PD)信号。
一名40岁诊断为回纹型风湿症的日本女性因持续性前足疼痛和行走困难前来我科就诊。类风湿因子(RF)和抗瓜氨酸化蛋白抗体(ACPA)水平均升高。她的脚趾张开,跖趾(MTP)关节肿胀。PDUS显示跖间滑囊炎伴轻度MTP滑膜炎。
我们根据2010年美国风湿病学会和欧洲抗风湿病联盟的RA分类标准进行综合判断,诊断为RA。
我们给予患者每周6.0毫克甲氨蝶呤(MTX)和每日2.0毫克泼尼松龙(PSL),随后将MTX增加至每周10毫克。
经过这些治疗后,患者症状有所改善。截至撰写本文时,患者的缓解状态已维持超过2个月。
她的病例表明,PDUS有助于检测前足滑囊炎,并且通过PDUS检测前足滑囊炎可能为RA的早期诊断提供机会。