Araujo James L, Worman Howard J
Department of Medicine, Columbia University, New York, New York, USA.
Department of Medicine, Columbia University, New York, New York, USA Department of Pathology and Cell Biology Columbia University, New York, New York, USA.
BMJ Case Rep. 2015 May 6;2015:bcr2015210303. doi: 10.1136/bcr-2015-210303.
Despite the widespread use of herbal and dietary supplements (HDS), serious cases of hepatotoxicity have been reported. The popular herbal weight loss supplement, Hydroxycut, has previously been implicated in acute liver injury. Since its introduction, Hydroxycut has undergone successive transformations in its formulation; yet, cases of liver injury have remained an ongoing problem. We report a case of a 41-year-old Hispanic man who developed acute hepatocellular liver injury with associated nausea, vomiting, jaundice, fatigue and asterixis attributed to the use of a newer formulation of Hydroxycut, SX-7 Clean Sensory. The patient required hospitalisation and improved with supportive therapy. Despite successive transformations in its formulation, potential liver injury appears to remain an ongoing problem with Hydroxycut. Our case illustrates the importance of obtaining a thorough medication history, including HDS, regardless of new or reformulated product marketing efforts.
尽管草药和膳食补充剂（HDS）被广泛使用，但仍有严重肝毒性病例的报道。流行的草药减肥补充剂Hydroxycut此前曾被认为与急性肝损伤有关。自推出以来，Hydroxycut的配方经历了多次变革；然而，肝损伤病例仍然是一个持续存在的问题。我们报告了一例41岁的西班牙裔男性病例，该患者因使用一种新型配方的Hydroxycut（SX-7 Clean Sensory）而出现急性肝细胞肝损伤，并伴有恶心、呕吐、黄疸、疲劳和扑翼样震颤。患者需要住院治疗，并通过支持性治疗后病情好转。尽管Hydroxycut的配方不断变革，但潜在的肝损伤似乎仍然是一个持续存在的问题。我们的病例说明了获取全面用药史的重要性，包括草药和膳食补充剂，无论新产品或重新配方产品的营销力度如何。
