Jacini Francesca, Sorrentino Pierpaolo, Lardone Anna, Rucco Rosaria, Baselice Fabio, Cavaliere Carlo, Aiello Marco, Orsini Mario, Iavarone Alessandro, Manzo Valentino, Carotenuto Anna, Granata Carmine, Hillebrand Arjan, Sorrentino Giuseppe
Department of Motor Sciences and Wellness, Parthenope University of Naples, Naples, Italy.
Institute for Diagnosis and Cure Hermitage Capodimonte, Naples, Italy.
Front Aging Neurosci. 2018 Dec 6;10:400. doi: 10.3389/fnagi.2018.00400. eCollection 2018.
There is general agreement that the neuropathological processes leading to Alzheimer's disease (AD) begin decades before the clinical onset. In order to detect early topological changes, we applied functional connectivity and network analysis to magnetoencephalographic (MEG) data obtained from 16 patients with amnestic Mild Cognitive Impairment (aMCI), a prodromal stage of AD, and 16 matched healthy control (HCs). Significant differences between the two groups were found in the theta band, which is associated with memory processes, in both temporal poles (TPs). In aMCI, the degree and betweenness centrality (BC) were lower in the left superior TP, whereas in the right middle TP the BC was higher. A statistically significant negative linear correlation was found between the BC of the left superior TP and a delayed recall score, a sensitive marker of the "hippocampal memory" deficit in early AD. Our results suggest that the TPs, which are involved early in AD pathology and belong to the memory circuitry, have an altered role in the functional network in aMCI.
人们普遍认为，导致阿尔茨海默病（AD）的神经病理过程在临床发病前数十年就已开始。为了检测早期的拓扑变化，我们对从16名遗忘型轻度认知障碍（aMCI，AD的前驱阶段）患者和16名匹配的健康对照（HCs）获得的脑磁图（MEG）数据应用了功能连接和网络分析。在与记忆过程相关的θ波段中，两组在双侧颞极（TPs）均存在显著差异。在aMCI中，左上颞极的度中心性和介数中心性（BC）较低，而在右中颞极BC较高。左上颞极的BC与延迟回忆得分之间存在统计学上显著的负线性相关，延迟回忆得分是早期AD中“海马记忆”缺陷的敏感标志物。我们的结果表明，早期参与AD病理且属于记忆回路的颞极在aMCI的功能网络中作用发生了改变。
