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The effect of raisins on biomarkers of endothelial function and oxidant damage; an open-label and randomized controlled intervention.葡萄干对血管内皮功能和氧化损伤生物标志物的影响：一项开放标签和随机对照干预研究。
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Tumor Diameter is an Easy and Useful Predictor of Recurrence in Stage II Colorectal Cancer.肿瘤直径是II期结直肠癌复发的一个简单且有用的预测指标。
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Clinical follow-up does not improve survival after resection of stage I-III colorectal cancer: A cohort study.临床随访不能提高 I-III 期结直肠癌切除术后的生存率：一项队列研究。
Int J Surg. 2015 May;17:67-71. doi: 10.1016/j.ijsu.2015.03.017. Epub 2015 Mar 28.
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Role of serum carcinoembryonic antigen in the detection of colorectal cancer before and after surgical resection.血清癌胚抗原在结直肠癌手术前后检测中的作用。
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血小板内血管内皮生长因子和血小板衍生生长因子：癌胚抗原阴性结直肠癌的新生物标志物？

Intraplatelet Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor: New Biomarkers in Carcinoembryonic Antigen-Negative Colorectal Cancer?

作者信息

Chater Charbel, Bauters Anne, Beugnet Claire, M'Ba Lena, Rogosnitzky Moshe, Zerbib Philippe

机构信息

Digestive Surgery and Transplantation Unit, Hôpital Huriez, Lille University Medical Center, Lille Nord de France University, Lille, France.

Department of Hematology and Transfusion, Centre de Biologie et Pathologie, Lille University Medical Center, Lille, France.

出版信息

Gastrointest Tumors. 2018 Sep;5(1-2):32-37. doi: 10.1159/000486894. Epub 2018 Feb 16.

DOI:10.1159/000486894
PMID:30574479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6288628/
Abstract

BACKGROUND/AIM: Colorectal cancer (CRC) is associated with high incidence and mortality rates. Carcinoembryonic antigen (CEA), a prognostic biomarker for recurrent CRC following curative resection, suffers from low sensitivity, especially in early-stage screening. Intraplatelet angiogenesis regulators (IPAR), such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), have been identified as important regulators of tumor growth in CRC. The aim of this study was to confirm the higher preoperative level of IPAR (VEGF and PDGF) in CRC patients compared to controls and to measure IPAR in CEA-negative CRC patients.

METHODS

The data and blood of 30 CRC patients and 30 presumably healthy controls were prospectively analyzed and compared.

RESULTS

We confirmed elevated preoperative intraplatelet VEGF and PDGF levels in CRC patients compared to controls. Importantly, IPAR were significantly elevated even in CEA-negative CRC patients.

CONCLUSION

Elevated preoperative intraplatelet VEGF and PDGF levels in CRC patients suggest new possibilities for postoperative monitoring in CRC patients, especially when CEA is negative.

摘要

背景/目的：结直肠癌（CRC）的发病率和死亡率都很高。癌胚抗原（CEA）作为根治性切除术后复发性CRC的一种预后生物标志物，其敏感性较低，尤其是在早期筛查中。血小板内血管生成调节因子（IPAR），如血管内皮生长因子（VEGF）和血小板衍生生长因子（PDGF），已被确定为CRC肿瘤生长的重要调节因子。本研究的目的是确认CRC患者术前IPAR（VEGF和PDGF）水平高于对照组，并测量CEA阴性CRC患者的IPAR。

方法

前瞻性分析并比较了30例CRC患者和30例可能健康的对照者的数据和血液。

结果

我们证实，与对照组相比，CRC患者术前血小板内VEGF和PDGF水平升高。重要的是，即使在CEA阴性的CRC患者中，IPAR也显著升高。

结论

CRC患者术前血小板内VEGF和PDGF水平升高，为CRC患者术后监测提供了新的可能性，尤其是在CEA为阴性时。