Mortazavi Hamed, Shafiei Shervin, Sadr Soroush, Safiaghdam Hannaneh
Oral Health Prev Dent. 2018;16(6):499-507. doi: 10.3290/j.ohpd.a41655.
Dysgeusia is an unpleasant alteration in taste. It can affect the nutritional and psychological status and decrease the quality of life of patients. It may be caused by nerve injury, head and neck trauma or surgery, infections, radiotherapy and drugs, but certain aetiological factors have not yet been identified. Understanding dysgeusia as a drug side effect is important for practitioners. The aim of this systematic review was to provide detailed information about dysgeusia in patients receiving different common medications.
An electronic search was conducted in MEDLINE, Google Scholar and Scopus databases, and studies were selected according to our inclusion criteria. We included studies on human subjects that reported dysgeusia as a drug side effect.
Thirty-four eligible studies were included in the systematic review. Thirty-five drugs were found in the literature to be correlated to dysgeusia. The most commonly reported offending drugs were from keratolytic agents, chemotherapeutic and cancer medication, antihistamine, antibiotics and angiotensin-converting enzyme inhibitors.
The quality of evidence was low in most reviewed studies. More studies with standard methodology are needed in this field. However, physicians and dental practitioners must consider the probability of dysgeusia as an adverse side effect when prescribing certain medications.
味觉障碍是一种味觉的不良改变。它会影响患者的营养和心理状况，并降低其生活质量。其可能由神经损伤、头颈部创伤或手术、感染、放疗及药物引起，但某些病因尚未明确。对从业者而言，将味觉障碍理解为药物副作用很重要。本系统评价的目的是提供接受不同常用药物治疗的患者味觉障碍的详细信息。
在MEDLINE、谷歌学术和Scopus数据库中进行电子检索，并根据纳入标准选择研究。我们纳入了将味觉障碍报告为药物副作用的人体研究。
34项符合条件的研究被纳入该系统评价。文献中发现35种药物与味觉障碍相关。最常报告的致病药物来自角质溶解剂、化疗和癌症用药、抗组胺药、抗生素及血管紧张素转换酶抑制剂。
大多数纳入评价的研究证据质量较低。该领域需要更多采用标准方法的研究。然而，医生和牙科从业者在开具某些药物处方时必须考虑味觉障碍作为不良副作用的可能性。
