Department of Oral Medicine, Academic Center of Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Department of Oral and Maxillofacial Surgery, Academic UMC, University of Amsterdam, Amsterdam, The Netherlands.
Oral Dis. 2020 Jan;26(1):213-223. doi: 10.1111/odi.13199. Epub 2019 Nov 11.
Oral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug-induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision making whether a taste disorder can be due to use of drugs by providing a comprehensive overview of drugs with taste disorders as an adverse effect.
The national drug information database for Dutch pharmacists, based on scientific drug information, guidelines, and summaries of product characteristics, was analyzed for drug-induced taste disorders. "MedDRA classification" and "Anatomic Therapeutical Chemical codes" were used to categorize the results.
Of the 1,645 drugs registered in the database, 282 (17%) were documented with "dysgeusia" and 61 (3.7%) with "hypogeusia." Drug-induced taste disorders are reported in all drug categories, but predominantly in "antineoplastic and immunomodulating agents," "antiinfectives for systemic use," and "nervous system." In ~45%, "dry mouth" coincided as adverse effect with taste disorders.
Healthcare professionals are frequently confronted with drugs reported to cause taste disorders. This article provides an overview of these drugs to support clinicians in their awareness, diagnosis, and treatment of drug-induced taste disorders.
口腔保健专业人员经常会遇到每天使用药物的患者。这些药物可能会引起味觉障碍作为不良反应。讨论药物引起的味觉障碍的文献比较分散。本文旨在通过全面概述具有味觉障碍不良反应的药物，为口腔保健专业人员在判断味觉障碍是否可能是由于药物使用引起提供支持。
分析了基于科学药物信息、指南和产品特性摘要的荷兰药剂师国家药物信息数据库，以确定药物引起的味觉障碍。使用“MedDRA 分类”和“解剖治疗化学代码”对结果进行分类。
在数据库中注册的 1645 种药物中，有 282 种（17%）记录为“味觉障碍”，61 种（3.7%）记录为“味觉减退”。味觉障碍在所有药物类别中均有报道，但主要在“抗肿瘤和免疫调节药物”、“全身抗感染药物”和“神经系统”中报道。约 45%的情况下，味觉障碍与不良反应“口干”同时发生。
医疗保健专业人员经常会遇到报告引起味觉障碍的药物。本文提供了这些药物的概述，以支持临床医生对药物引起的味觉障碍的认识、诊断和治疗。
