a Department of Head and Neck-Endocrine Oncology , Moffitt Cancer Center , Tampa , FL , USA.
b Department of Anatomic Pathology , Moffitt Cancer Center , Tampa , FL , USA.
Expert Rev Mol Diagn. 2019 Jan;19(1):63-70. doi: 10.1080/14737159.2019.1559056. Epub 2018 Dec 21.
: The majority of squamous cell carcinoma (SCC) of the oropharynx, one of the sites within the head and neck region, is now associated with high-risk human papillomavirus (HPV) in North America. Several modalities are available to determine the HPV status, however, the understanding of each assay in its application and limitations is essential for accurate interpretation and appropriate utilization of results in management of these patients. : This expert review will cover the role of HPV in head and neck squamous cell carcinoma (HNSCC), indications for HPV testing, HPV detection methods in tumors, saliva and serum, and exploiting HPV status as a prognostic biomarker of clinical outcome in HNSCC. : The HPV status is the most significant diagnostic and prognostic biomarker in HNSCC, specifically in the oropharynx. Research underway is currently delineating the role of HPV and p16 testing in non-oropharyngeal sites. While the feasibility of non-invasive serum and saliva testing for HPV detection has been established, the clinical application of these assays is still evolving.
口咽鳞状细胞癌（SCC）是头颈部区域的一种癌症，大多数口咽 SCC 现在与北美高危型人乳头瘤病毒（HPV）有关。有几种方法可以确定 HPV 状态，但了解每种检测方法的应用和局限性对于准确解释和正确利用这些患者的检测结果至关重要。
本专家综述将涵盖 HPV 在头颈部鳞状细胞癌（HNSCC）中的作用、HPV 检测的适应证、肿瘤、唾液和血清中的 HPV 检测方法，以及利用 HPV 状态作为 HNSCC 临床结果的预后生物标志物。
HPV 状态是 HNSCC 中最重要的诊断和预后生物标志物，特别是在口咽部位。目前正在进行的研究正在描绘 HPV 和 p16 检测在非口咽部位的作用。虽然已经证实了非侵入性血清和唾液 HPV 检测的可行性，但这些检测方法的临床应用仍在不断发展。
