Lavoue V, Lavoue P, Turk P, Brasseur P, Druilhe P
Laboratoire de Parasitologie Biomédicale, Institut Pasteur, Paris.
Trop Med Parasitol. 1988 Sep;39(3):249-50.
The response to chloroquine of 49 Plasmodium falciparum isolates from the Northern dry areas of Cameroon was assessed by 7 day in-vivo assays. Twenty seven patients were treated with the standard 25 mg/kg dose, and 22 received a reduced, but frequently used, 10 mg/kg dose. The results of these in vivo assays are in agreement with in-vitro data showing a low prevalence and a low degree of chloroquine resistance. In contrast with P. falciparum isolates from Southern Cameroon, no case of RII or RIII resistance was detected in the North. Clearance of parasite was delayed in 4 of the 22 patients treated with 10 mg/kg, and for one of them parasites remained up to day 7 despite subnormal but appropriate chloroquine blood concentrations.
通过7天的体内试验评估了来自喀麦隆北部干旱地区的49株恶性疟原虫分离株对氯喹的反应。27名患者接受了标准的25mg/kg剂量治疗，22名患者接受了降低但常用的10mg/kg剂量治疗。这些体内试验的结果与体外数据一致，显示氯喹耐药性的低流行率和低程度。与喀麦隆南部的恶性疟原虫分离株相比，北部未检测到RII或RIII耐药病例。在接受10mg/kg治疗的22名患者中，有4名患者的寄生虫清除延迟，其中1名患者尽管氯喹血药浓度低于正常但仍合适，寄生虫一直持续到第7天。
