头孢克洛、头孢噻吩和头孢羟氨苄对大肠杆菌、肺炎克雷伯菌和奇异变形杆菌的体外活性存在差异。
Variable in vitro activity of cefaclor, cephalothin and cefadroxil against Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis.
作者信息
Larsson P, Lincoln K, Lind L, Sandberg T
机构信息
Department of Clinical Bacteriology, University of Göteborg, Sweden.
出版信息
Scand J Infect Dis. 1988;20(4):421-4. doi: 10.3109/00365548809032479.
The in vitro activity of cefaclor, cephalothin and cefadroxil to 50 Escherichia coli, 23 Klebsiella pneumoniae and 20 Proteus mirabilis strains was tested with the disc diffusion and microdilution plate techniques. Cefaclor was more active than cefadroxil, while cephalothin was intermediate. The differences seriously affected the classification into the routine SIR system. For susceptibility testing we question the use of cephalothin as a class representative of oral cephalosporins.
采用纸片扩散法和微量稀释平板法检测了头孢克洛、头孢噻吩和头孢羟氨苄对50株大肠埃希菌、23株肺炎克雷伯菌和20株奇异变形杆菌的体外活性。头孢克洛比头孢羟氨苄活性更强，而头孢噻吩活性中等。这些差异严重影响了其在常规SIR系统中的分类。对于药敏试验，我们质疑将头孢噻吩用作口服头孢菌素类的代表药物。
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