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伴有退行性椎体滑脱是否会影响单纯减压治疗退变性腰椎管狭窄症的疗效?一项比较研究的荟萃分析。

Does Concomitant Degenerative Spondylolisthesis Influence the Outcome of Decompression Alone in Degenerative Lumbar Spinal Stenosis? A Meta-Analysis of Comparative Studies.

作者信息

Wang Miao, Luo Xiao Ji, Ye Yong Jie, Zhang Zhi

机构信息

Department of Orthopedics, Suining Central Hospital, Suining, People's Republic of China.

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

出版信息

World Neurosurg. 2019 Mar;123:226-238. doi: 10.1016/j.wneu.2018.11.246. Epub 2018 Dec 18.

Abstract

OBJECTIVE

To investigate whether the preoperative presence of degenerative spondylolisthesis (DS) worsens the outcome of patients undergoing decompression alone for degenerative lumbar stenosis.

METHODS

We conducted a comprehensive search in the PubMed, Embase, and Cochrane Library databases. All comparative studies were included in this meta-analysis. The literature search, data extraction, and quality assessment were conducted by 2 independent reviewers. The functional outcomes were clinical scores and reoperation rate. The radiologic outcomes were slippage rate and postoperative instability rate.

RESULTS

A total of 11 studies with 1081 cases, including 469 cases of degenerative lumbar stenosis with DS (DS group) and 612 degenerative lumbar stenosis without spondylolisthesis (noDS group), were enrolled in our meta-analysis. There were no significant differences between the 2 groups for functional outcomes in terms of Japanese Orthopedic Association score, Japanese Orthopedic Association recovery rate, Oswestry Disability Index score, visual analog scale back/leg, and reoperation rate after decompression alone. For the radiologic outcomes, slippage rate was found not changed significantly before and after minimally invasive decompression alone in the DS group and the postoperative instability rate did not differ significantly between the 2 groups after decompression alone by a minimally invasive method.

CONCLUSIONS

Our meta-analysis revealed that concomitant DS (Meyerding grade I-II) does not influence the outcome of decompression alone in degenerative lumbar spinal stenosis, especially when a minimally invasive procedure was performed and patients did not have predominant symptoms of mechanical back pain. The presence of DS should not be an indication for fusion surgery in degenerative lumbar spinal stenosis.

摘要

目的

探讨术前存在退变性腰椎滑脱(DS)是否会使仅接受减压手术治疗的退变性腰椎管狭窄症患者的预后变差。

方法

我们在PubMed、Embase和Cochrane图书馆数据库中进行了全面检索。所有比较研究均纳入本荟萃分析。文献检索、数据提取和质量评估由2名独立审阅者进行。功能结局指标为临床评分和再手术率。影像学结局指标为滑脱率和术后不稳率。

结果

本荟萃分析共纳入11项研究,1081例患者,其中包括469例合并DS的退变性腰椎管狭窄症患者(DS组)和612例无腰椎滑脱的退变性腰椎管狭窄症患者(无DS组)。两组在日本骨科协会评分、日本骨科协会恢复率、Oswestry功能障碍指数评分、视觉模拟量表背部/腿部评分以及单纯减压术后再手术率等功能结局方面无显著差异。对于影像学结局,DS组单纯微创减压前后的滑脱率无显著变化,且两组经微创方法单纯减压术后的术后不稳率无显著差异。

结论

我们的荟萃分析表明,合并DS(Meyerding分级I-II级)并不影响退变性腰椎管狭窄症单纯减压的预后,尤其是在进行微创手术且患者没有主要的机械性背痛症状时。DS的存在不应成为退变性腰椎管狭窄症融合手术的指征。

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