Gray B N, Walker C, Bennett R C
Aust N Z J Surg. 1977 Oct;47(5):648-55. doi: 10.1111/j.1445-2197.1977.tb06597.x.
Numerous changes occur in the sera of patients bearing malignant neoplasms. These changes may take the form of appearance of oncofetal proteins that are normally not detectable in non-cancer-bearing patients, or an alteration in the normally present serum constituents such as the serum proteins. Monitoring of these serum factors may be of considerable value in assessing the progress of cancer patients following treatment of their primary tumour. This paper reviews progress in this area to date and documents our early results with six non-specific serum factors (total protein, total protein hexose, total protein hexosamine, ceruloplasmin, alpha-1-antitrypsin, and haptoglobin), in 64 patients bearing a variety of malignant neoplasms in various stages of the disease. Present methods of postoperative assessment of cancer patients are inadequate for detecting early recurrence. Preliminary results indicate that the nonspecific serum factors that we are studying may be of considerable value for monitoring of cancer patients, and may also possibly serve as a diagnostic screen in high-risk groups.
患有恶性肿瘤的患者血清会发生许多变化。这些变化可能表现为癌胚蛋白的出现，而在未患癌症的患者中通常检测不到这些蛋白，或者表现为正常存在的血清成分（如血清蛋白）的改变。监测这些血清因子对于评估癌症患者原发肿瘤治疗后的病情进展可能具有重要价值。本文综述了该领域迄今为止的进展，并记录了我们对64例患有处于疾病不同阶段的各种恶性肿瘤的患者使用六种非特异性血清因子（总蛋白、总蛋白己糖、总蛋白己糖胺、铜蓝蛋白、α-1抗胰蛋白酶和触珠蛋白）的早期结果。目前术后评估癌症患者的方法不足以检测早期复发。初步结果表明，我们正在研究的非特异性血清因子可能对监测癌症患者具有重要价值，也可能作为高危人群的诊断筛查手段。
