Ulisko I N, Stepanova M V, Vertiev Iu V, Ratiner Iu A, Baturo A P
Zh Mikrobiol Epidemiol Immunobiol. 1988 Aug(8):48-53.
Out of 4,082 Escherichia strains isolated from 989 hospitalized patients with acute enteric infections 2,979 strains belonged to 139 O-groups and the remaining strains could not by typed with O-sera (O1-O164) or were in the serological R-form. 19.3% of the strains isolated from 354 patients showed a positive reaction for thermolabile enterotoxin (TLET) determined in the radioimmunoassay. Escherichia with pronounced reaction for TLET were isolated from 5.5% of the patients. The serological picture of Escherichia with a positive reaction for TLET comprised 78 O-groups, showed practically no variations in children of different age and adult patients and was related to the intensity of reaction for TLET. The number of enterotoxigenic Escherichia greatly varied within individual O-groups: from 3.1 +/- 3.63% (O11) to 100 +/- 9.81% (O114) of the total number of known strains in these O-groups. In most O-groups the number of enterotoxigenic strains varied from 10% to 50%. The most widely spread serovars of etiologically important enterotoxigenic Escherichia belonged to 24 O-groups and were often isolated as monocultures. The capacity for producing TLET (and, probably, some other antigenically related substances) in widely spread among Escherichia; still, the determination of enterotoxicity is a necessary, but not sufficient criterion of their etiological importance in acute enteric infections.
从989例急性肠道感染住院患者中分离出4082株大肠杆菌，其中2979株属于139个O群，其余菌株无法用O血清（O1 - O164）分型或呈血清学R型。从354例患者中分离出的菌株，19.3%在放射免疫分析中对不耐热肠毒素（TLET）呈阳性反应。5.5%的患者分离出对TLET反应明显的大肠杆菌。对TLET呈阳性反应的大肠杆菌血清学图谱包含78个O群，在不同年龄儿童和成年患者中几乎没有差异，且与TLET反应强度有关。产肠毒素大肠杆菌的数量在各个O群中差异很大：占这些O群已知菌株总数的3.1±3.63%（O11）至100±9.81%（O114）。在大多数O群中，产肠毒素菌株的数量在10%至50%之间。具有重要病因学意义的产肠毒素大肠杆菌最广泛传播的血清型属于24个O群，且常作为单一培养物分离出来。产TLET（可能还有其他一些抗原相关物质）的能力在大肠杆菌中广泛存在；然而，肠毒性的测定是其在急性肠道感染中病因学重要性的必要但不充分标准。
