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[儿童急性肠道感染中分离出的弯曲杆菌的产肠毒素活性及其临床评估]

[The enterotoxigenic activity of Campylobacter isolates taken in acute intestinal infections in children and its clinical assessment].

作者信息

Gorelov A V, Vorotyntseva N V, Domaradskaia T I, Ezepchuk Iu V, Bondarenko V M, Zhukovitskiĭ V G

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1994 Jul-Aug(4):7-10.

PMID:7992543
Abstract

The screening of Campylobacter clinical isolates in ELISA with the use of nitrocellulose filters as solid phase has revealed the possibility of the detection of enterotoxins. The capacity for producing thermolabile enterotoxin has been found in 75.9%, Shiga-like enterotoxin in 56.4% and both enterotoxins in 31.3% of the tested C. jejuni and C. coli strains. The influence of the enterotoxigenic capacity of the strains under study on the severity of Campylobacter infection and on its numerous clinical manifestations in children has been established.

摘要

使用硝酸纤维素滤膜作为固相,通过酶联免疫吸附测定法(ELISA)对弯曲杆菌临床分离株进行筛选,结果显示有可能检测到肠毒素。在所检测的空肠弯曲菌和结肠弯曲菌菌株中,发现75.9%的菌株具有产生不耐热肠毒素的能力,56.4%的菌株具有产生志贺样肠毒素的能力,31.3%的菌株同时具有这两种肠毒素的产生能力。已经确定了所研究菌株的产肠毒素能力对弯曲杆菌感染严重程度及其在儿童中的众多临床表现的影响。

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