Cleland L G, Bell D A, Willans M, Saurino B C
Arthritis Rheum. 1978 Mar;21(2):183-91. doi: 10.1002/art.1780210202.
HLA profiles in 103 members of 4 separate kindred with multiple occurrence of SLE were compatible with the presence of a disease susceptibility factor linked to HLA or a direct effect of antigens B8, A11, and B35 on disease expression. Serum ANA was found in 52.9% of consanguineous, 56.5% of nonconsanguineous relatives of SLE probands, and 5% of controls, a finding that suggests the presence of a transmissible agent in the families. By contrast, lymphocytotoxic antibodies were not increased in relatives compared to controls.
在4个不同的系统性红斑狼疮（SLE）多发家族的103名成员中，人类白细胞抗原（HLA）谱与一种与HLA相关的疾病易感性因素的存在或抗原B8、A11和B35对疾病表达的直接影响相符。在SLE先证者的52.9%的近亲、56.5%的非近亲亲属以及5%的对照中发现了血清抗核抗体（ANA），这一发现表明这些家族中存在一种可传播的病原体。相比之下，与对照相比，亲属中的淋巴细胞毒性抗体并未增加。
