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Adolescent Health Providers' Willingness to Prescribe Pre-Exposure Prophylaxis (PrEP) to Youth at Risk of HIV Infection in the United States.美国青少年健康提供者对有感染 HIV 风险的青少年开具暴露前预防(PrEP)药物的意愿。
J Adolesc Health. 2018 Aug;63(2):242-244. doi: 10.1016/j.jadohealth.2018.03.016. Epub 2018 May 26.
2
Targeting Human Immunodeficiency Virus Pre-Exposure Prophylaxis to Adolescent Sexual Minority Males in Higher Prevalence Areas of the United States: A Modeling Study.针对美国高流行地区青少年性少数男性的人免疫缺陷病毒暴露前预防目标:一项建模研究。
J Adolesc Health. 2018 Mar;62(3):311-319. doi: 10.1016/j.jadohealth.2017.09.023. Epub 2017 Dec 13.
3
Safety and Feasibility of Antiretroviral Preexposure Prophylaxis for Adolescent Men Who Have Sex With Men Aged 15 to 17 Years in the United States.美国15至17岁男男性行为青少年接受抗逆转录病毒暴露前预防的安全性和可行性
JAMA Pediatr. 2017 Nov 1;171(11):1063-1071. doi: 10.1001/jamapediatrics.2017.2007.
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Brief Report: Recovery of Bone Mineral Density After Discontinuation of Tenofovir-Based HIV Pre-exposure Prophylaxis.简短报告:停用基于替诺福韦的HIV暴露前预防后骨矿物质密度的恢复情况
J Acquir Immune Defic Syndr. 2017 Oct 1;76(2):177-182. doi: 10.1097/QAI.0000000000001475.
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PrEP Awareness, Familiarity, Comfort, and Prescribing Experience among US Primary Care Providers and HIV Specialists.美国初级保健提供者和HIV专家对暴露前预防(PrEP)的认知、熟悉程度、接受度及处方经验
AIDS Behav. 2017 May;21(5):1256-1267. doi: 10.1007/s10461-016-1625-1.
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Brief Report: Preventing HIV-1 Infection in Women Using Oral Preexposure Prophylaxis: A Meta-analysis of Current Evidence.简短报告:使用口服暴露前预防措施预防女性感染HIV-1:当前证据的荟萃分析。
J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):606-608. doi: 10.1097/QAI.0000000000001160.
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A Cross-Sectional Online Survey of HIV Pre-Exposure Prophylaxis Adoption Among Primary Care Physicians.一项针对初级保健医生中艾滋病病毒暴露前预防措施采用情况的横断面在线调查。
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A Medical Care Missed Opportunity: Preexposure Prophylaxis and Young Black Men Who Have Sex With Men.一个医疗错失的机会:暴露前预防与年轻的男男性行为黑人男性
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An HIV Preexposure Prophylaxis Demonstration Project and Safety Study for Young MSM.一项针对年轻男男性行为者的HIV暴露前预防示范项目及安全性研究。
J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):21-29. doi: 10.1097/QAI.0000000000001179.
10
Adolescent Human Immunodeficiency Virus Care Providers' Attitudes Toward the Use of Oral Pre-Exposure Prophylaxis in Youth.青少年人类免疫缺陷病毒护理提供者对青少年使用口服暴露前预防的态度
AIDS Patient Care STDS. 2016 Jul;30(7):339-48. doi: 10.1089/apc.2016.0048.

一个大都市地区的初级保健医生对青少年使用 HIV 暴露前预防的态度和意向。

Primary Care Physician Attitudes and Intentions Toward the Use of HIV Pre-exposure Prophylaxis in Adolescents in One Metropolitan Region.

机构信息

Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

出版信息

J Adolesc Health. 2019 May;64(5):581-588. doi: 10.1016/j.jadohealth.2018.10.300. Epub 2018 Dec 19.

DOI:10.1016/j.jadohealth.2018.10.300
PMID:30578115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6478546/
Abstract

PURPOSE

Understanding the attitudes of physicians toward the use of pre-exposure prophylaxis (PrEP) for HIV prevention among youth is critical to improving access to PrEP. We examined PrEP-related attitudes among physicians who provide primary care to 13- to 21-year-old adolescents.

METHODS

Individual, in-depth, semistructured interviews were conducted with 38 physicians from adolescent medicine, family practice, internal medicine/medicine-pediatrics, obstetrics/gynecology, and pediatrics who care for any adolescents younger than 18 years. Interviews assessed familiarity with PrEP, perceived benefits and barriers to providing PrEP to adolescents, facilitating factors for prescribing PrEP, and likelihood of recommending and prescribing PrEP to adolescents.

RESULTS

Mean age was 44.6 years (standard deviation 10.9). Fourteen physicians (37%) reported being somewhat or very familiar with PrEP. Perceived benefits of prescribing PrEP included decreased acquisition/rates of HIV, improved provision of sexual health services, and improved patient awareness of HIV risk. Barriers to PrEP were reported at the patient (e.g., lack of acceptability to patients), provider (e.g., concerns about patient adherence, safety/side effects, parents as a barrier to PrEP use), and system (e.g., high cost) levels. Facilitating factors for prescribing PrEP included low cost/coverage by insurance, physician education about PrEP, patient educational materials, and clinical guidelines for PrEP use in youth. A higher proportion of physicians reported being highly or somewhat likely to recommend (N = 16, 42%) than prescribe PrEP (N = 13, 34%).

CONCLUSIONS

In this study of primary care physician attitudes toward PrEP prescribing for adolescents, physicians identified numerous barriers to providing PrEP. Addressing these barriers may increase adolescents' access to PrEP.

摘要

目的

了解医生对青少年使用暴露前预防(PrEP)预防 HIV 的态度,对于改善 PrEP 的可及性至关重要。我们调查了为 13 至 21 岁青少年提供初级保健的医生的 PrEP 相关态度。

方法

对来自青少年医学、家庭实践、内科/医学-儿科学、妇产科和儿科的 38 名医生进行了个人、深入、半结构化的访谈,这些医生为任何年龄小于 18 岁的青少年提供护理。访谈评估了他们对 PrEP 的熟悉程度、为青少年提供 PrEP 的预期益处和障碍、开具 PrEP 的促进因素,以及向青少年推荐和开具 PrEP 的可能性。

结果

平均年龄为 44.6 岁(标准差为 10.9)。14 名医生(37%)报告称对 PrEP 有一定程度或非常熟悉。开处方 PrEP 的预期益处包括降低 HIV 的获得/感染率、改善性健康服务的提供,以及提高患者对 HIV 风险的认识。PrEP 的障碍报告在患者(例如,患者不接受)、提供者(例如,对患者依从性、安全性/副作用、父母对 PrEP 使用的障碍的担忧)和系统(例如,高成本)水平。开具 PrEP 的促进因素包括保险的低成本/覆盖范围、关于 PrEP 的医生教育、患者教育材料和青少年使用 PrEP 的临床指南。更多的医生报告称非常或有些可能推荐(N=16,42%)而不是开 PrEP(N=13,34%)。

结论

在这项对初级保健医生对青少年 PrEP 处方态度的研究中,医生确定了提供 PrEP 的许多障碍。解决这些障碍可能会增加青少年获得 PrEP 的机会。