National Institute for Agricultural and Food Research and Technology (INIA), Department of Environment, Carretera de la Coruña, Km 7, Madrid, Spain.
Inkoa Sistemas S.L. Poligono Industrial Ribera de Axpe, 11, 48950 Erandio, Vizcaya, Spain; CBET Research Group, Department of Zoology and Animal Cell Biology, Faculty of Science and Technology and Research Centre for Experimental Marine Biology and Biotechnology PIE, University of the Basque Country UPV/EHU, Basque Country, Spain.
Sci Total Environ. 2019 Mar 25;658:416-423. doi: 10.1016/j.scitotenv.2018.12.186. Epub 2018 Dec 13.
One of the aims of the European project LIFE-COMBASE is to build a computational tool to predict the acute toxicity for aquatic organisms of biocidal active substances and its environmental degradation products. A database was implemented compiling toxicity data for these substances in organisms of the freshwater/marine and sewage treatment plant compartments. The goal of this study is to analyze the compiled data to identify the possible hazard of these compounds for the aquatic compartments. Several official and scientific databases were consulted. Data from 196 biocidal substances and 206 environmental metabolites were collected for the taxonomic groups, including fish, invertebrates, algae and sewage treatment plant (STP) microorganisms. Substances were categorized for their toxicity in four groups, considering values of L(E)C, according to EU Regulation (EC) No 1272/2008. >50% of the parent were located in category 1 (L(E)C ≤ 1 mg/L) for fish, invertebrates and algae, indicating a high toxicity for the freshwater/marine compartments. However >60% were not toxic for STP microorganisms. Metabolites were mainly less toxic than the parent compounds, but 22-36% presented the same toxicity and ~6% were more toxic. No toxicological information was found for ~50% of the metabolites for fish, invertebrates and algae, reaching the 96% for the microorganisms. In addition, information on toxicity to the STP microorganisms was only found for 40% of the parent compounds. The high percentage of toxic metabolites and the scarcity of data for these compounds indicate the need to further study their impact in the aquatic compartments.
欧洲项目 LIFE-COMBASE 的目标之一是构建一种计算工具，以预测杀菌活性物质及其环境降解产物对水生生物的急性毒性。为此，建立了一个数据库，用于编译这些物质在淡水/海洋生物和污水处理厂（STP）微生物组中的毒性数据。本研究的目的是分析编译的数据，以确定这些化合物对水生生物的潜在危害。参考了几个官方和科学数据库。为包括鱼类、无脊椎动物、藻类和 STP 微生物在内的分类群收集了 196 种杀菌物质和 206 种环境代谢物的数据。根据欧盟法规 (EC) No 1272/2008，根据 L(E)C 值，将这些物质分为四类毒性，考虑到其毒性值。 >50%的母体化合物在鱼类、无脊椎动物和藻类中位于第 1 类（L(E)C ≤ 1 mg/L），表明对淡水/海洋生物具有高毒性。然而，>60%的母体化合物对 STP 微生物没有毒性。代谢物的毒性通常低于母体化合物，但有 22-36%的代谢物具有相同的毒性，约 6%的代谢物毒性更强。约 50%的代谢物对鱼类、无脊椎动物和藻类没有毒理学信息，对微生物的这一比例达到 96%。此外，仅对 40%的母体化合物找到了对 STP 微生物的毒性信息。有毒代谢物的高比例和这些化合物数据的稀缺性表明需要进一步研究它们对水生生物的影响。
