Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Reprod Toxicol. 2019 Mar;84:26-31. doi: 10.1016/j.reprotox.2018.12.006. Epub 2018 Dec 21.
Endometriosis is a complex disease impacted by the hormonal and immune systems. Cytokines and chemokines are serum biomarkers that maybe useful to develop a noninvasive disease diagnosis. Individuals in the Fernald Community Cohort were exposed to uranium, a heavy metal with radioactive properties and estrogenic potential; therefore, serum samples from women in this cohort with or without uranium and with or without endometriosis were compared for alterations in chemokine, cytokine, and matrix metalloproteinase (MMP) levels. Control women were matched to endometriosis cases by uranium exposure, age, and body mass index. MMP levels were not altered. Five chemokines and one cytokine significantly increased in endometriosis cases versus controls irrespective of uranium exposure. Uranium exposure alone was associated with an increase in inflammatory chemokines. The majority of the elevated chemokines in endometriosis cases play important roles in attracting T helper-2 cells, which may be vital to understanding the immune response in endometriosis.
子宫内膜异位症是一种受激素和免疫系统影响的复杂疾病。细胞因子和趋化因子是血清生物标志物，可能有助于开发非侵入性疾病诊断方法。费尔南德社区队列中的个体接触了铀，这是一种具有放射性和雌激素潜力的重金属；因此，比较了队列中患有或不患有子宫内膜异位症且接触或不接触铀的女性的趋化因子、细胞因子和基质金属蛋白酶 (MMP) 水平的变化。对照女性通过铀暴露、年龄和体重指数与子宫内膜异位症病例相匹配。MMP 水平没有改变。五种趋化因子和一种细胞因子在子宫内膜异位症病例中与对照组相比显著增加，无论铀暴露如何。单独的铀暴露与炎症趋化因子的增加有关。子宫内膜异位症病例中大多数升高的趋化因子在吸引 T 辅助 2 细胞方面发挥着重要作用，这对于理解子宫内膜异位症中的免疫反应可能至关重要。
