Laboratory of Early Markers of Neurodegeneration, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Neurological Institute, Tel Aviv Medical Center, Tel-Aviv, Israel; Department of Neurology, Sackler School of Medicine, Tel Aviv University, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Neurological Institute, Tel Aviv Medical Center, Tel-Aviv, Israel; Department of Neurology, Sackler School of Medicine, Tel Aviv University, Israel.
Clin Neurophysiol. 2019 Feb;130(2):224-230. doi: 10.1016/j.clinph.2018.11.019. Epub 2018 Dec 8.
To investigate EEG changes during an auditory odd-ball task while walking (dual-task) in young adults, older adults, and patients with Parkinson's disease.
11 young adults, 10 older adults, and 10 patients with Parkinson's disease (PD) performed an auditory oddball task during standing and walking on a treadmill, while wearing a wireless EEG cap. The amplitude and latency of P300 were compared between groups and within conditions using linear mix model analysis. Gait was evaluated using wearable sensors and cognition was assessed using the Color Trail Test.
P300 latency became longer during walking in all groups (p = 0.005). During walking, older adults (p = 0.005) and patients with PD (p = 0.001) showed prolonged P300 latency compared to young adults. Significant task by group interaction was found in P300 amplitude (p = 0.008). Patients with PD demonstrated reduced P300 amplitude during walking compared to standing (p = 0.023). Among all subjects, better motor and cognitive performance correlated with shorter P300 latency (r = 0.457, p = 0.014 and r = 0.431, p = 0.040, respectively).
These findings provide direct evidence of the physiological recruitment of attentional networks during walking and their impact by ageing and disease.
This study is the first to report on changes in P300 latency and amplitude during dual-task oddball walking in older adults and patients with PD.
研究年轻人、老年人和帕金森病患者在行走（双重任务）时进行听觉Oddball 任务时的脑电图变化。
11 名年轻人、10 名老年人和 10 名帕金森病（PD）患者在跑步机上站立和行走时佩戴无线 EEG 帽，进行听觉 Oddball 任务。使用线性混合模型分析比较组间和组内条件下 P300 的振幅和潜伏期。使用可穿戴传感器评估步态，使用颜色追踪测试评估认知。
所有组在行走时 P300 潜伏期均延长（p=0.005）。在行走时，与年轻人相比，老年人（p=0.005）和 PD 患者（p=0.001）的 P300 潜伏期延长。在 P300 振幅方面，发现任务与组之间存在显著的交互作用（p=0.008）。与站立时相比，PD 患者在行走时 P300 振幅降低（p=0.023）。在所有受试者中，更好的运动和认知表现与更短的 P300 潜伏期相关（r=0.457，p=0.014 和 r=0.431，p=0.040）。
这些发现为注意力网络在行走时的生理募集及其对衰老和疾病的影响提供了直接证据。
这是第一项报道老年人和 PD 患者在双重任务 Oddball 行走期间 P300 潜伏期和振幅变化的研究。
