帕金森病患者行走过程中抑制控制受损：一项脑电图研究

Impaired Inhibitory Control During Walking in Parkinson's Disease Patients: An EEG Study.

作者信息

Sosnik Ronen, Danziger-Schragenheim Shani, Possti Daniel, Fahoum Firas, Giladi Nir, Hausdorff Jeffrey M, Mirelman Anat, Maidan Inbal

机构信息

Faculty of Electrical Engineering, Holon Institute of Technology (H.I.T.), Holon, Israel.

Laboratory of Early Markers of Neurodegeneration (LEMON), Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Israel.

出版信息

J Parkinsons Dis. 2022;12(1):243-256. doi: 10.3233/JPD-212776.

DOI:10.3233/JPD-212776

PMID:34569972

Abstract

BACKGROUND

The performance on a visual Go/NoGo (VGNG) task during walking has been used to evaluate the effect of gait on response inhibition in young and older adults; however, no work has yet included Parkinson's disease (PD) patients for whom such changes may be even more enhanced.

OBJECTIVE

In this study, we aimed to explore the effect of gait on automatic and cognitive inhibitory control phases in PD patients and the associated changes in neural activity and compared them with young and older adults.

METHODS

30 PD patients, 30 older adults, and 11 young adults performed a visual Go/NoGo task in a sitting position and during walking on a treadmill while their EEG activity and gait were recorded. Brain electrical activity was evaluated by the amplitude, latency, and scalp distribution of N2 and P300 event related potentials. Mix model analysis was used to examine group and condition effects on task performance and brain activity.

RESULTS

The VGNG accuracy rates in PD patients during walking were lower than in young and older adults (F = 5.619, p = 0.006). For all groups, N2 latency during walking was significantly longer than during sitting (p = 0.013). In addition, P300 latency was significantly longer in PD patients (p < 0.001) and older adults (p = 0.032) during walking compared to sitting and during 'NoGo' trials compared with 'Go' trials. Moreover, the young adults showed the smallest number of electrodes for which a significant differential activation between sit to walk was observed, while PD patients showed the largest with N2 being more strongly manifested in bilateral parietal electrodes during walking and in frontocentral electrodes while seated.

CONCLUSION

The results show that response inhibition during walking is impaired in older subjects and PD patients and that increased cognitive load during dual-task walking relates to significant change in scalp electrical activity, mainly in parietal and frontocentral channels.

摘要

背景

在年轻人和老年人中，步行时视觉Go/NoGo（VGNG）任务的表现已被用于评估步态对反应抑制的影响；然而，尚未有研究纳入帕金森病（PD）患者，而这类患者的此类变化可能更为明显。

目的

在本研究中，我们旨在探究步态对PD患者自动和认知抑制控制阶段的影响以及神经活动的相关变化，并将其与年轻人和老年人进行比较。

方法

30名PD患者、30名老年人和11名年轻人在坐位以及在跑步机上行走时执行视觉Go/NoGo任务，同时记录他们的脑电图活动和步态。通过N2和P300事件相关电位的幅度、潜伏期和头皮分布来评估脑电活动。混合模型分析用于检验组间和条件对任务表现及脑活动的影响。

结果

PD患者步行时的VGNG准确率低于年轻人和老年人（F = 5.619，p = 0.006）。对于所有组，步行时的N2潜伏期显著长于坐位时（p = 0.013）。此外，与坐位相比，PD患者（p < 0.001）和老年人（p = 0.032）在步行时以及与“Go”试验相比在“NoGo”试验期间，P300潜伏期显著更长。而且，年轻人中观察到从坐位到步行有显著差异激活的电极数量最少，而PD患者最多，N2在步行时双侧顶叶电极以及坐位时额中央电极表现得更为明显。