内生水藓中的两个新苯甲酮。

Two new benzophenones from endohydric moss .

机构信息

a College of Life Science, Hebei Normal University , Shijiazhuang , P.R. China.

b Hebei Province Academy of Chinese Medicine Sciences , Shijiazhuang , P.R. China.

出版信息

Nat Prod Res. 2019 Oct;33(19):2750-2754. doi: 10.1080/14786419.2018.1499638. Epub 2018 Dec 22.

DOI:10.1080/14786419.2018.1499638

PMID:30580587

Abstract

Two new benzophenones ( and ), were isolated from the endohydric moss . Their structures were elucidated by spectroscopic methods including extensive 2 D NMR techniques. Compound is the first example of benzophenone with a rare cyclopropylacetamide from the natural resources. Compounds and were screened their cytotoxicity against five cancer cell lines (HCT-116, A-549, MCF-7, HepG2, A-375,), and no cytotoxic activities were observed (IC > 100 μM).

摘要

从内生水藓中分离得到两个新的苯甲酮类化合物（和）。通过包括扩展 2D NMR 技术在内的光谱方法阐明了它们的结构。化合物是天然产物中第一个具有罕见环丙基乙酰胺的苯甲酮类化合物。对化合物和进行了对五种癌细胞系（HCT-116、A-549、MCF-7、HepG2、A-375）的细胞毒性筛选，均未观察到细胞毒性活性（IC > 100μM）。