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五加科植物(L. F. 菲利普森)的叶甲醇提取物可逆转雄性大鼠中阿米替林诱导的性功能障碍。

Leaf-Methanolic Extract of (Araliaceae) (L. F. Phillipson) Reverses Amitriptyline-Induced Sexual Dysfunction in Male Rats.

作者信息

Besong Egbe B, Ateufack G, Babiaka Smith B, Kamanyi Albert

机构信息

Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, Buea, Cameroon.

Animal Physiology and Phytopharmacology Laboratory, Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon.

出版信息

Biochem Res Int. 2018 Nov 15;2018:2869727. doi: 10.1155/2018/2869727. eCollection 2018.


DOI:10.1155/2018/2869727
PMID:30581624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6276499/
Abstract

The people of the Bayangi tribe (Manyu Division) of Cameroon have used the leaves of (Araliaceae) traditionally for decades as an aphrodisiac. In order to scientifically investigate this folk claim, we evaluated the effects of the leaf-aqueous extract of on the sexual behavior of normal male rats. The present study was designed to assess the effects of the leaf-methanolic extract of on amitriptyline-induced sexual dysfunction in male rats. Sexually impaired male rats were randomly divided into 4 groups of 8 rats each. Group 1 received 10 ml/kg distilled water, while group 2 was given 6 mg/kg Viagra. Groups 3 and 4 received 46.5 and 93 mg/kg of the leaf-methanolic extract, respectively. Female rats were made receptive by ovariectomy and subsequent hormonal treatment. Sexual behavior parameters were monitored on days 1, 7, 14, and 21 by pairing each male to a receptive female. The extract-treated rats registered significant decrease in mount latency (ML) and intromission latency (IL); nonsignificant increase in mount frequency (MF), intromission frequency (IF), and penile licking (PL); significant decrease in postejaculatory interval (PEI); contrasting effects in ejaculation latency (EL); and mean intromission interval (MII). Both doses of the extract also provoked a significant increase in relative weight of testes, but had no significant effect on the plasma hormonal profile. These findings are similar to those obtained with normal male rats and show that the leaf-methanolic extract of could constitute a potential solution to male sexual impairment.

摘要

喀麦隆巴扬吉部落(曼尤分区)的人们几十年来一直将刺通草(五加科)的叶子传统地用作壮阳药。为了科学地研究这一民间说法,我们评估了刺通草叶水提取物对正常雄性大鼠性行为的影响。本研究旨在评估刺通草叶甲醇提取物对阿米替林诱导的雄性大鼠性功能障碍的影响。性能力受损的雄性大鼠被随机分为4组,每组8只。第1组接受10毫升/千克蒸馏水,而第2组给予6毫克/千克伟哥。第3组和第4组分别接受46.5和93毫克/千克的叶甲醇提取物。通过卵巢切除术和随后的激素治疗使雌性大鼠具有接受性。在第1、7、14和21天,通过将每只雄性与一只接受性雌性配对来监测性行为参数。提取物处理的大鼠在爬跨潜伏期(ML)和插入潜伏期(IL)上显著降低;在爬跨频率(MF)、插入频率(IF)和阴茎舔舐(PL)上无显著增加;射精后间隔(PEI)显著降低;射精潜伏期(EL)和平均插入间隔(MII)有相反的影响。两种剂量的提取物还使睾丸相对重量显著增加,但对血浆激素水平无显著影响。这些发现与在正常雄性大鼠中获得的结果相似,表明刺通草叶甲醇提取物可能是解决男性性功能障碍的一种潜在方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/fc088ef7b5b4/BRI2018-2869727.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/ae0ae3c5239e/BRI2018-2869727.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/1a4fa4e7e00d/BRI2018-2869727.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/68ed69fa12ce/BRI2018-2869727.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/158675abe1cf/BRI2018-2869727.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/312d9d703361/BRI2018-2869727.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/fc088ef7b5b4/BRI2018-2869727.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/ae0ae3c5239e/BRI2018-2869727.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/1a4fa4e7e00d/BRI2018-2869727.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/68ed69fa12ce/BRI2018-2869727.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/158675abe1cf/BRI2018-2869727.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/312d9d703361/BRI2018-2869727.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fe/6276499/fc088ef7b5b4/BRI2018-2869727.009.jpg

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引用本文的文献

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[3]
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