Ghanbarizadeh Saeed Reza, Dinpanah Hossein, Ghasemi Reza, Salahshour Yaser, Sardashti Samaneh, Kamali Mostafa, Khatibi Seyed Reza
Department of urology, 9-Day Hospital, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Emergency Department, 9-Day Hospital, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Emerg (Tehran). 2018;6(1):e47. Epub 2018 Aug 2.
About 5% of visits to emergency departments are made up of conversion disorder cases. This study was designed with the aim of comparing the effectiveness of quetiapine and haloperidol in controlling conversion disorder symptoms.
The present single-blind clinical trial has been performed on patients with conversion disorder (based on the DSM-IV definition) presenting to emergency department of 9-Day Hospital, Torbat Heydariyeh, Iran, from January 2017 until May 2018.
73 patients were allocated to haloperidol and 71 to quetiapine group. Mean age of these patients was 32.03 ± 12.80 years (62.50% female). Two groups were similar regarding the baseline characteristics. Within 30 minutes, 90.41% of haloperidol cases and 91.55% of quetiapine cases were relieved (p=0.812). The most common side effects after 30 minutes were extrapyramidal symptoms (9.59%) in the haloperidol group and fatigue and sleepiness (7.04%) in the quetiapine group. Extrapyramidal symptoms was significantly higher than the quetiapine group (p=0.013).
The results of the present study showed that although quetiapine and haloperidol have a similar effect in relieving the patients from conversion disorder symptoms, the prevalence of extrapyramidal symptoms is significantly lower in the group under treatment with quetiapine. Therefore, it seems that quetiapine is a safer drug compared to haloperidol.
急诊科就诊患者中约5%为转换障碍病例。本研究旨在比较喹硫平和氟哌啶醇在控制转换障碍症状方面的有效性。
本单盲临床试验于2017年1月至2018年5月在伊朗托尔巴特海达里耶九天医院急诊科对符合转换障碍（基于《精神疾病诊断与统计手册》第四版定义）的患者进行。
73例患者被分配到氟哌啶醇组，71例被分配到喹硫平组。这些患者的平均年龄为32.03±12.80岁（62.50%为女性）。两组在基线特征方面相似。30分钟内，氟哌啶醇组90.41%的病例和喹硫平组91.55%的病例症状得到缓解（p=0.812）。30分钟后最常见的副作用在氟哌啶醇组为锥体外系症状（9.59%），在喹硫平组为疲劳和嗜睡（7.04%）。锥体外系症状在氟哌啶醇组显著高于喹硫平组（p=0.013）。
本研究结果表明，虽然喹硫平和氟哌啶醇在缓解转换障碍症状方面效果相似，但喹硫平治疗组锥体外系症状的发生率显著更低。因此，与氟哌啶醇相比，喹硫平似乎是一种更安全的药物。
