Idrees Sana, Sridhar Jayanth, Kuriyan Ajay E
Int Ophthalmol Clin. 2019 Winter;59(1):221-240. doi: 10.1097/IIO.0000000000000258.
Proliferative vitreoretinopathy (PVR) is the most common cause for failure of rhegmatogenous retinal detachment repair and is characterized by the growth and contraction of cellular membranes within the vitreous cavity and on both sides of the retinal surface as well as intraretinal fibrosis. Currently, PVR is thought to be an abnormal wound healing response that is primarily driven by inflammatory, retinal, and RPE cells. At this time, surgery is the only management option for PVR as there is no proven pharmacologic agent for the treatment or prevention of PVR. Laboratory research to better understand PVR pathophysiology and clinical trials of various agents to prevent PVR formation are ongoing.
增殖性玻璃体视网膜病变(PVR)是孔源性视网膜脱离修复失败的最常见原因,其特征是玻璃体腔内及视网膜表面两侧的细胞膜生长和收缩以及视网膜内纤维化。目前,PVR被认为是一种异常的伤口愈合反应,主要由炎症细胞、视网膜细胞和视网膜色素上皮(RPE)细胞驱动。目前,手术是PVR唯一的治疗选择,因为尚无经证实的用于治疗或预防PVR的药物。旨在更好地理解PVR病理生理学的实验室研究以及各种预防PVR形成药物的临床试验正在进行中。