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孔源性视网膜脱离手术治疗后的复发率及危险因素:一项回顾性队列研究。

Incidence and risk factors for recurrence after surgical treatment of rhegmatogenous retinal detachment: a retrospective cohort study.

作者信息

Tawfik Abdelrahman M, Eweidah Ahmed Mohamed, Hassanien Rawan Adel, Mohamed Shrouk F, Kasem Rawan Ashraf, Ghoneem Mohammed

机构信息

Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

出版信息

Int J Retina Vitreous. 2025 May 22;11(1):59. doi: 10.1186/s40942-025-00680-7.

Abstract

BACKGROUND

Rhegmatogenous retinal detachment (RRD) is a vision-threatening ophthalmic emergency requiring prompt surgical intervention. Despite advancements in surgical techniques, recurrence remains a significant challenge, leading to additional surgeries and poorer visual outcomes. This study aimed to evaluate the incidence and risk factors for RRD recurrence following surgical repair in an Egyptian tertiary care setting.

METHODS

A retrospective cohort study was conducted at Alexandria Main University Hospital, Egypt, including 134 patients who underwent RRD surgery (pars plana vitrectomy [PPV] or scleral buckling [SB]) between March and September 2023. Demographic, clinical, and surgical variables were evaluated. Recurrence was defined as anatomical detachment after initial surgical success within a 6-month follow-up period. Statistical analyses included chi-square tests and multivariate logistic regression to identify independent risk factors.

RESULTS

The recurrence rate was 24.6%, with early recurrence (≤ 6 weeks) occurring in 14.9% of cases. PPV had a significantly higher recurrence rate (34.8%) compared to SB (19.3%) (p = 0.049). Univariate analysis identified right eye laterality (p = 0.02), high myopia (p = 0.015), proliferative vitreoretinopathy (PVR) (p < 0.001), and ocular comorbidities (p = 0.018) as significant risk factors. Multivariate analysis confirmed right eye laterality (OR: 3.7, p = 0.016), high myopia (OR: 0.34, p = 0.04), and PVR (OR: 0.15, p = 0.005) as independent predictors. Surgeon experience significantly influenced outcomes in univariate analysis (p = 0.001), but not in adjusted models.

CONCLUSIONS

RRD recurrence remains prevalent occurring in nearly one-quarter of repaired RRD cases, predominantly within the early postoperative period. Surgical technique, laterality, and ocular characteristics significantly impacted recurrence risk. These findings highlight the need for individualized surgical planning and enhanced surveillance in high-risk patients, particularly during the critical first postoperative weeks.

摘要

背景

孔源性视网膜脱离(RRD)是一种威胁视力的眼科急症,需要及时进行手术干预。尽管手术技术有所进步,但复发仍然是一个重大挑战,会导致额外的手术和更差的视力结果。本研究旨在评估埃及三级医疗环境中RRD手术修复后复发的发生率和危险因素。

方法

在埃及亚历山大主大学医院进行了一项回顾性队列研究,纳入了2023年3月至9月期间接受RRD手术(玻璃体切除术[PPV]或巩膜扣带术[SB])的134例患者。对人口统计学、临床和手术变量进行了评估。复发定义为初次手术成功后6个月随访期内出现的解剖性脱离。统计分析包括卡方检验和多因素逻辑回归,以确定独立危险因素。

结果

复发率为24.6%,早期复发(≤6周)发生率为14.9%。与SB(19.3%)相比,PPV的复发率显著更高(34.8%)(p = 0.049)。单因素分析确定右眼侧别(p = 0.02)、高度近视(p = 0.015)、增殖性玻璃体视网膜病变(PVR)(p < 0.001)和眼部合并症(p = 0.018)为显著危险因素。多因素分析证实右眼侧别(OR:3.7,p = 0.016)、高度近视(OR:0.34,p = 0.04)和PVR(OR:0.15,p = 0.005)为独立预测因素。在单因素分析中,外科医生经验对结果有显著影响(p = 0.001),但在调整模型中无影响。

结论

RRD复发仍然很普遍,在近四分之一的RRD修复病例中发生,主要发生在术后早期。手术技术、侧别和眼部特征显著影响复发风险。这些发现强调了在高危患者中进行个体化手术规划和加强监测的必要性,尤其是在术后关键的最初几周。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1e1/12096617/da6d7197e9fe/40942_2025_680_Fig1_HTML.jpg

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