J Assoc Nurses AIDS Care. 2019 Jan-Feb;30(1):42-50. doi: 10.1097/JNC.0000000000000040.
Neurocognitive impairment (NCI) is common in people aging with HIV and can adversely affect health-related quality of life. However, early NCI may be largely asymptomatic and neurocognitive function is rarely assessed in the context of routine clinical care. In this study, we considered the utility of two assessment tools as screens for NCI in patients attending a community-based clinic (N = 58; mean age = 57 years): the Montreal Cognitive Assessment (MoCA) and a 3-item cognitive concerns questionnaire derived from the HIV Dementia Scale. Health-related quality of life and depression/anxiety were also measured. Indication of NCI using the MoCA was more prevalent compared to the 3-item questionnaire and was associated with the patients' initial antiretroviral therapy commencing between the years of 1997 and 2001, independently of age. Findings of the MoCA were not confounded by existing mood disorders, unlike the 3-item questionnaire. Therefore, we suggest implementing the MoCA as an initial screen for NCI.
神经认知障碍（NCI）在老年 HIV 感染者中很常见，会对与健康相关的生活质量产生不利影响。然而，早期的 NCI 可能大多没有症状，并且在常规临床护理中很少评估神经认知功能。在这项研究中，我们考虑了两种评估工具在社区诊所就诊的患者中的作用，将其作为 NCI 的筛查工具（N=58；平均年龄=57 岁）：蒙特利尔认知评估（MoCA）和从 HIV 痴呆量表衍生的 3 项认知问题问卷。还测量了与健康相关的生活质量和抑郁/焦虑。与 3 项问卷相比，MoCA 对 NCI 的指示更为普遍，并且与患者在 1997 年至 2001 年间开始的初始抗逆转录病毒治疗有关，这与年龄无关。MoCA 的发现与现有的情绪障碍无关，与 3 项问卷不同。因此，我们建议将 MoCA 作为 NCI 的初始筛查工具。
