Zając Joanna, Gomółka Ewa, Szot Wojciech
Jagiellonian University Medical College, Dep. Hygiene and Dietetics.
Toxicological Laboratory, Diagnostics Department, University Hospital, Kraków, Poland.
Ann Agric Environ Med. 2018 Dec 20;25(4):625-629. doi: 10.26444/aaem/75940. Epub 2017 Aug 28.
The aim of presented study was comparison of urinary 1-hydroxypyrene concentration among coke plant workers (before and after working week) and among non-exposed individuals from the same area, taking smoking status into consideration.
647 coke plant workers and 206 individuals living in the same area were analysed with respect to urinary 1-OHP concentration and smoking status. Urinary samples were measured using high performance liquid chromatography (HPLC) with fluorescent detection. Concentrations were normalized with respect to creatinine concentration. For workers, two samples were collected before and after working week. Multiple regression was performed to distinguish and quantify the influence of cigarette smoking and occupational PAH exposition on the urinary 1-OHP levels.
Average urinary 1-OHP concentration of samples collected before the working week was: 1.07 μg/g; after the working week: 2.36 μg/g and for control: 0.74 μg/g. The samples collected at the beginning of the working week were not suitable for assessment of the workers' background (non-occupational) exposition. Smoking cigarettes induced a rise in urinary 1-OHP level by 16%, on average (CI: 5% - 28%), and working for a whole working week at the coke plant made urinary 1-OHP levels, on average, 3.21 times higher (CI: 2.91 - 3.54).
Working at the coke plant increases significantly urinary 1-OHP concentration in comparison to non-occupationally exposed individuals, both for samples collected before and after the working week. Smoking remains a significant source of PAHs exposition, despite the fact that occupational exposure is greater. Health promotion programmes should address both the occupational health risks reduction and smoking prevention.
本研究的目的是比较焦化厂工人（工作周前后）与来自同一地区未接触者的尿中1-羟基芘浓度，并考虑吸烟状况。
对647名焦化厂工人和206名居住在同一地区的人员进行了尿中1-OHP浓度和吸烟状况分析。尿样采用高效液相色谱法（HPLC）荧光检测进行测定。浓度以肌酐浓度进行标准化。对于工人，在工作周前后各采集两份样本。进行多元回归以区分和量化吸烟和职业性多环芳烃暴露对尿中1-OHP水平的影响。
工作周前采集的样本尿中1-OHP平均浓度为：1.07μg/g；工作周后为：2.36μg/g，对照组为：0.74μg/g。工作周开始时采集的样本不适合评估工人的背景（非职业性）暴露情况。吸烟平均使尿中1-OHP水平升高16%（置信区间：5% - 28%），而在焦化厂工作一整个工作周使尿中1-OHP水平平均升高3.21倍（置信区间：2.91 - 3.54）。
与非职业性暴露个体相比，在焦化厂工作显著增加了尿中1-OHP浓度，无论是工作周前还是工作周后采集的样本。尽管职业暴露更大，但吸烟仍是多环芳烃暴露的一个重要来源。健康促进计划应同时关注职业健康风险降低和吸烟预防。
