a Postgraduate Program in Biotechnology - RENORBIO , Focal Point - Federal University of Piauí , Teresina , Brazil.
b Department of Pharmacy , Federal University of Piauí , Teresina , Brazil.
Expert Opin Ther Pat. 2019 Feb;29(2):115-126. doi: 10.1080/13543776.2019.1562547. Epub 2019 Jan 15.
Primary dysmenorrhea (PD) is another term for idiopathic menstrual cramps. Treatments include the use of oral non-steroidal anti-inflammatory drugs (NSAIDs). These drugs have several side effects. The objective of this study was to perform a systematic review on the transdermal administration of drugs and the use of alternative therapies for the treatment of PD.
The article bases were Web of Science, PubMed and Sciencedirect and the patent bases were INPI, EPO and WIPO with publications on Primary Dysmenorrhea and associations with Transdermal Administration; Complementary Therapies and Medicinal Plants. 21 articles and 12 patents were analyzed. The results demonstrate the need for alternative therapies for the treatment of PD, with greater effectiveness and lower side effects, mainly in an attempt to reduce the intensity and duration of pain as well as reducing the continuous use of medications.
The study of technological prospection highlighted the relevant importance in seeking new methods for the relief of the symptoms provoked by this condition. The perspectives coexist in the discovery of new natural and biotechnological pharmacological applications, mainly in the development of new devices capable of facilitating and optimizing this form of administration in an attempt to reduce side effects.
原发性痛经（PD）是特发性月经痉挛的另一个术语。治疗方法包括使用口服非甾体抗炎药（NSAIDs）。这些药物有几种副作用。本研究的目的是对药物的经皮给药和替代疗法治疗 PD 进行系统评价。
该文章的基础是 Web of Science、PubMed 和 Sciencedirect，专利基础是 INPI、EPO 和 WIPO，涉及原发性痛经和与经皮给药相关的出版物；补充疗法和药用植物。分析了 21 篇文章和 12 项专利。结果表明，需要替代疗法来治疗 PD，以提高疗效，降低副作用，主要是为了减轻疼痛的强度和持续时间，并减少药物的连续使用。
技术展望研究强调了寻求缓解这种疾病引起的症状的新方法的重要性。在发现新的天然和生物技术药理学应用方面存在着共同的观点，主要是在开发新的设备方面，这些设备能够促进和优化这种给药方式，以减少副作用。
