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硝苯地平致无牙颌患者牙龈增生：一例 1 年随访报告。

Nifedipine induced gingival enlargement in an edentulous patient: a case report with one year follow up.

机构信息

Department of Diagnostic Sciences and Oral biology , College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.

Department of Periodontology, Mamata Dental College, Khammam, India.

出版信息

BMC Oral Health. 2018 Dec 27;18(1):227. doi: 10.1186/s12903-018-0690-4.

DOI:10.1186/s12903-018-0690-4
PMID:30587167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6307157/
Abstract

BACKGROUND

Gingival enlargement due to calcium channel blockers is a common complaint reported by patients. It can be localized or generalized and can range from mild to severe, affecting patients appearance and function. Nifedipine induced gingival enlargement is noticed only in 10 % of patients and very few cases of Nifedipine induced gingival enlargement in an edentulous patient have been documented in the literature.

CASE PRESENTATION

Here in, we report a case of gingival enlargement in a 70 year old hypertensive edentulous patient who was on low dose Nifedipine therapy. Patient wanted complete dentures. We planned to excise the overgrowth and followed up for 1 year.

CONCLUSION

Nifedipine induced gingival enlargement noticed only in 10 % of patients. Hence, there is a need for physicians and dentist to make a coordinated treatment plan and practice care while prescribing these drugs which are associated with gingival overgrowth.

摘要

背景

钙通道阻滞剂引起的牙龈增生是患者常报告的一种常见问题。它可以是局部的或广泛的，可以从轻度到重度，影响患者的外观和功能。硝苯地平引起的牙龈增生仅在 10%的患者中被注意到，并且文献中很少有记录在案的无牙患者中硝苯地平引起的牙龈增生的病例。

病例介绍

在这里，我们报告了一例 70 岁高血压无牙患者的牙龈增生病例，该患者正在接受低剂量硝苯地平治疗。患者需要全口义齿。我们计划切除过度生长的组织，并进行了 1 年的随访。

结论

硝苯地平引起的牙龈增生仅在 10%的患者中被注意到。因此，医生和牙医在开具这些与牙龈过度生长相关的药物时，需要制定协调的治疗计划并进行护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/f5f5cf97f5f6/12903_2018_690_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/810b2bccde03/12903_2018_690_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/87719ad1d1a5/12903_2018_690_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/aa9bbd5b332a/12903_2018_690_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/9291b9fe4457/12903_2018_690_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/6fd29a9cadb5/12903_2018_690_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/951498b6885a/12903_2018_690_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/6203b6c2640b/12903_2018_690_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/f5f5cf97f5f6/12903_2018_690_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/810b2bccde03/12903_2018_690_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/87719ad1d1a5/12903_2018_690_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/aa9bbd5b332a/12903_2018_690_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/9291b9fe4457/12903_2018_690_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/6fd29a9cadb5/12903_2018_690_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/951498b6885a/12903_2018_690_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/6203b6c2640b/12903_2018_690_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99a3/6307157/f5f5cf97f5f6/12903_2018_690_Fig8_HTML.jpg

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Influence of mast cells in drug-induced gingival overgrowth.药物性牙龈增生中 mast cells 的影响。
Mediators Inflamm. 2013;2013:275172. doi: 10.1155/2013/275172. Epub 2013 Jan 28.
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Nifedipine-induced gingival enlargement: Correlation with dose and oral hygiene.硝苯地平引起的牙龈增生：与剂量和口腔卫生的相关性。
心血管疾病患者的药物性牙龈增生
World J Cardiol. 2021 Apr 26;13(4):68-75. doi: 10.4330/wjc.v13.i4.68.
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Prevalence of gingival overgrowth among elderly patients under amlodipine therapy at a large Indian teaching hospital.在一家大型印度教学医院中，接受氨氯地平治疗的老年患者中牙龈增生的患病率。
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Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features.苯妥英钠所致牙龈增生：分子、免疫及炎症特征综述
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