School of Public Health, Capital Medical University, Beijing, 100069, China.
FuXing Hospital, Capital Medical University, Beijing, 100069, China.
Lipids Health Dis. 2018 Dec 26;17(1):294. doi: 10.1186/s12944-018-0936-9.
Recent research had shown blood glucose was not the only cause of large for gestational age infant (LGA), the contributions of other fuels such as lipids also play an important role in fetal development. However the association between maternal triglyceride at early trimester and the risk of LGA has not yet been clearly elucidated. This research evaluated the association of maternal early trimester TG level with the risk of LGA infant in Chinese mothers.
2839 pregnant women were recruited at the first visit of their perinatal health care and followed up prospectively till after delivery. The demographic, maternal characteristics were extracted from a questionnaire. Infant characteristics were collected at delivery. Maternal fasting serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (HDL-C)levels, were measured in 68th, 16th, 24th, and 36th gestational weeks. Fasting serum glucose levels were measured at 68th, 24th, and 36th gestational weeks. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence intervals.
A consistently lower TG level was observed in mothers with non-LGA infant than mothers with LGA infant and TG level of mothers of LGA infants increased faster than that of control group. The incidence of LGA infants between two groups (TG<1.7 mmol/L and TG ≥ 1.7 mmol/L) was 14.46 and 26.63%, respectively. Mothers with the highest TG level (TG > 1.19 mmol/L) gave birth to infants with higher birth weight (BW) than the other two groups (TG < 0.70 mmol/L and TG:0.70~0.89 mmol/L). When stratified by pre-pregnancy body mass index (pre-BMI), a significantly positive association was founded between the maternal TG level at early trimester and the risk of LGA in non-overweight/obesity women (OR = 1.740, p = 0.034).
The findings suggested that high maternal TG level at very early trimester was associated with the increased risk of LGA in non-overweight/obesity pregnant women. Moreover, high maternal TG level at first trimester may be an early predictor of LGA.
最近的研究表明，血糖并不是巨大儿（LGA）的唯一原因，其他燃料如脂质的贡献也在胎儿发育中起着重要作用。然而，孕妇早期三酰甘油（TG）水平与 LGA 风险之间的关系尚未得到明确阐明。本研究评估了中国孕妇孕早期 TG 水平与 LGA 婴儿风险的关系。
2839 名孕妇在产前保健首次就诊时被招募，并前瞻性随访至分娩后。从问卷中提取人口统计学和孕产妇特征。在分娩时收集婴儿特征。在第 6-8、16、24 和 36 孕周测量孕妇空腹总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。在第 6-8、24 和 36 孕周测量空腹血糖水平。使用逻辑回归模型计算比值比（OR）和 95%置信区间。
与 LGA 婴儿的母亲相比，非 LGA 婴儿的母亲的 TG 水平始终较低，而 LGA 婴儿的母亲的 TG 水平增加得更快。两组（TG<1.7mmol/L 和 TG≥1.7mmol/L）的 LGA 婴儿发生率分别为 14.46%和 26.63%。TG 最高（TG>1.19mmol/L）的母亲所生婴儿的出生体重（BW）高于其他两组（TG<0.70mmol/L 和 TG：0.70~0.89mmol/L）。按孕前体重指数（pre-BMI）分层后，孕早期 TG 水平与非超重/肥胖女性的 LGA 风险之间存在显著正相关（OR=1.740，p=0.034）。
研究结果表明，孕早期高 TG 水平与非超重/肥胖孕妇的 LGA 风险增加有关。此外，孕早期高 TG 水平可能是 LGA 的早期预测指标。
