Uzair Bushra, Bano Asma, Niazi Muhammad Bilal Khan, Khan Farah, Habiba Ume, Khan Nimra Naeem, Khan Barkat Ali
Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.
Department of Microbiology, University of Haripur, Haripur Pakistan.
Pak J Pharm Sci. 2018 Nov;31(6 (Supplementary):2733-2736.
An antifungal compound 9, 10-dihydrophenanthrene - 2 - carboxylic acid was isolated from a marine derived bacterium Pseudomonas putida isolated from surface water samples of Karachi fish harbor coast line. The structure was explored using extensive 1D- and 2D-NMR spectroscopic techniques. The compound was found to be active against fungal strains obtained from clinical samples whereas strong activity was noted against Candida albicans with a MIC value of 20μg/ml, as the purified compound showed promising anticandidal activity a multidisciplinary approach is needed to explore further this compound as potential pharmacological lead compound against Candida spp and will add in the global hunt for clinically functional antifungal agents.
