白僵菌素K，一种源自海洋镰刀菌属的新型抗真菌白僵菌素类似物
Beauvericin K, a New Antifungal Beauvericin Analogue from a Marine-derived Fusarium sp.
作者信息
Xu Xiuli, Zhao Shujiang, Yu Ying, Chen Zhengkun, Shen Huihui, Zhou Li
出版信息
Nat Prod Commun. 2016 Dec;11(12):1825-1826.
PMID:30508343
Abstract
Chemical investigation of a Chinese collection of a marine-derived fungus, Fusarium sp., led to the characterization of beauvericin.K, a new analogue of beauvericin. The structure of the new compound was elucidated by detailed spectroscopic analysis, including ID and 2D NMR methods, and HRMS. Beauvericin K showed significant activity against the yeast Candida albicans with an IC50 value of 6.25 üg/mL..
摘要
对中国采集的一种海洋来源真菌镰刀菌属（Fusarium sp.）进行化学研究，得到了新的白僵菌素类似物白僵菌素K的表征。通过详细的光谱分析，包括一维和二维核磁共振方法以及高分辨质谱，阐明了该新化合物的结构。白僵菌素K对白色念珠菌显示出显著活性，IC50值为6.25μg/mL。
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