Suppa G, Pollavini G, Alberti D, Savonitto S
J Hypertens. 1988 Oct;6(10):787-90.
A multicentre study, involving 358 subjects, was carried out to evaluate the effects of a low-Na/high-K dietary salt in hypertensive patients receiving beta-blocker monotherapy. At the end of a 4-week treatment period with 200 mg slow-release metoprolol patients were randomly divided into two groups: one group was given common salt and the other the dietary salt. Both salts were given at table, in double-blind conditions over a period of 4 weeks. The dietary salt group showed a systolic and diastolic blood pressure (BP) reduction (4.2 and 3.0 mmHg, respectively, in the supine position and 4.0 and 2.5 mmHg in the standing position), which was virtually absent in the common salt group. A statistically significant difference between the two groups was found only between the systolic values (P less than 0.05). Twenty-four-hour urinary sodium excretion did not change in either group, while the excretion of 24-h urinary potassium increased significantly in the dietary salt group. It is concluded that in mild or moderately hypertensive patients already receiving a beta-blocker, ancillary treatment with a low-Na/high-K salt can be expected to lead to a further, slight reduction in systolic BP, probably due to the daily potassium load (around 20 mmol).
一项涉及358名受试者的多中心研究开展，以评估低钠/高钾膳食盐对接受β受体阻滞剂单一疗法的高血压患者的影响。在使用200毫克缓释美托洛尔进行4周治疗期结束时，患者被随机分为两组：一组给予普通食盐，另一组给予膳食盐。两种盐均在进餐时给予，在双盲条件下持续4周。膳食盐组收缩压和舒张压（BP）均降低（仰卧位时分别降低4.2和3.0 mmHg，站立位时降低4.0和2.5 mmHg），而普通食盐组几乎没有变化。两组之间仅在收缩压值上发现有统计学显著差异（P小于0.05）。两组24小时尿钠排泄均未改变，而膳食盐组24小时尿钾排泄显著增加。得出结论，在已经接受β受体阻滞剂治疗的轻度或中度高血压患者中，辅助使用低钠/高钾盐有望导致收缩压进一步轻微降低，可能是由于每日钾负荷（约20 mmol）所致。
