Arzilli F, Taddei S, Graziadei L, Bichisao E, Giovannetti R, Salvetti A
J Hypertens Suppl. 1986 Dec;4(5):S347-50.
To investigate whether a K-rich/Na-poor salt is able to reduce blood pressure, 10 mildly hypertensive inpatients (six males) aged 28-53 years, with supine diastolic blood pressure (DBP) greater than 95 mmHg after 5 days of hospitalization, on a standard diet containing about 20 mmol Na plus 4 g common salt (CS) were randomly given, in double-blind conditions, 2 g twice daily of either CS (five patients) or K-rich/Na-poor salt (five patients) to add to food for a further 8 days. Mean blood pressure was significantly (P less than 0.01) reduced to a similar extent in both groups in the first 4 days, and declined significantly (P less than 0.01) only in the K/Na group in the following 8 days, reaching values significantly (P less than 0.01) lower than those of the CS group. The heart rate did not change significantly while body weight decreased to a similar extent in both groups. Urinary sodium excretion was similarly and significantly (P less than 0.01) reduced in both groups in the first 4 days (CS 100.8 +/- 7.9 and K/Na 100.2 +/- 11.0 mmol/24 h, and remained unchanged in the CS group (109.9 +/- 4.3 mmol/24 h) but declined significantly (P less than 0.05) by about 50% in the K/Na group (62.9 +/- 3.6 mmol/24 h) in the following 8 days. Plasma renin activity (PRA) and plasma noradrenaline did not differ significantly between the two groups, nor among the days of treatment, but the mean blood pressure response to mental stress was reduced significantly (P less than 0.4) in the Na/K group compared with the CS group.(ABSTRACT TRUNCATED AT 250 WORDS)
为研究富钾/低钠盐是否能够降低血压，选取10例轻度高血压住院患者（6例男性），年龄在28至53岁之间，住院5天后仰卧位舒张压（DBP）大于95 mmHg，食用含约20 mmol钠加4 g普通盐（CS）的标准饮食，在双盲条件下，随机给予其中5例患者每日两次、每次2 g的CS，另外5例患者每日两次、每次2 g的富钾/低钠盐，添加到食物中再持续8天。在前4天，两组的平均血压均显著（P<0.01）降低至相似程度，而在接下来的8天中，仅富钾/低钠组血压显著（P<0.01）下降，降至显著（P<0.01）低于普通盐组的值。心率无显著变化，两组体重下降程度相似。在前4天，两组尿钠排泄均同样显著（P<0.01）减少（CS组为100.8±7.9 mmol/24小时，富钾/低钠组为100.2±11.0 mmol/24小时），普通盐组保持不变（109.9±4.3 mmol/24小时），而富钾/低钠组在接下来的8天中显著（P<0.05）下降约50%（62.9±3.6 mmol/24小时）。两组间血浆肾素活性（PRA）和血浆去甲肾上腺素在治疗期间各天均无显著差异，但与普通盐组相比，富钾/低钠组对精神应激的平均血压反应显著降低（P<0.4）。（摘要截选至250字）
