Mazzarello V, Donadu M G, Ferrari M, Piga G, Usai D, Zanetti S, Sotgiu M A
Skinlab, Department of Biomedical Sciences, University of Sassari, Sassari, Italy,
Clin Pharmacol. 2018 Dec 13;10:175-181. doi: 10.2147/CPAA.S180474. eCollection 2018.
Antibiotics that suppress are the standard treatment for acne but are becoming less effective, due to the appearance of antibiotic-resistant strains. Many plants are known to have innate antimicrobial action and can be used as alternatives to antibiotics; thus, it is necessary to prove their effectiveness in vivo. This study aimed to evaluate the anti-acne efficacy of a new cream based on three natural extracts, comparing it to erythromycin cream and placebo.
Sixty patients with mild to moderate acne vulgaris were randomly divided into three groups: treated with cream containing 20% propolis, 3% "tea tree oil", and 10% "" (PTAC) (n=20); or with 3 % erythromycin cream (ERC) (n=20); or with placebo (n=20). At baseline, after 15 and 30 days, investigators evaluated response to treatment by counting acne lesions through noninvasive measurements and macrophotography.
All the clinical and instrumental values studied were statistically different from placebo except for sebometry, pHmetry, and erythema index values, measured on healthy skin. Unlike in the placebo group, papular and scar lesions showed high erythema reduction after 15 and 30 days of PTAC and ERC application.
The PTAC formulation was better than ERC in reducing erythema scars, acne severity index, and total lesion count.
抑制痤疮丙酸杆菌的抗生素是痤疮的标准治疗方法，但由于抗生素耐药菌株的出现，其疗效正逐渐降低。许多植物具有天然抗菌作用，可作为抗生素的替代品；因此，有必要在体内证明它们的有效性。本研究旨在评估一种基于三种天然提取物的新型乳膏的抗痤疮疗效，并将其与红霉素乳膏和安慰剂进行比较。
60例轻至中度寻常痤疮患者被随机分为三组：分别使用含20%蜂胶、3%“茶树油”和10%“（此处原文缺失具体成分）”的乳膏（PTAC）治疗（n = 20）；或使用3%红霉素乳膏（ERC）治疗（n = 20）；或使用安慰剂治疗（n = 20）。在基线、15天和30天后，研究人员通过无创测量和微距摄影对痤疮皮损进行计数，以评估治疗反应。
除在健康皮肤上测量的皮脂测定、皮肤pH值测定和红斑指数值外，所有研究的临床和仪器测量值与安慰剂相比均有统计学差异。与安慰剂组不同，在应用PTAC和ERC 15天和30天后，丘疹和瘢痕皮损的红斑有明显减轻。
在减轻红斑瘢痕、痤疮严重程度指数和总皮损计数方面，PTAC配方优于ERC。
