Waranuch Neti, Phimnuan Preeyawass, Yakaew Swanya, Nakyai Wongnapa, Grandmottet Francois, Onlom Churanya, Srivilai Jukkarin, Viyoch Jarupa
Cosmetics and Natural Products Research Center, Faculty of Pharmaceutical Sciences Naresuan University, Phitsanulok 65000, Thailand.
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
Clin Cosmet Investig Dermatol. 2019 May 30;12:383-391. doi: 10.2147/CCID.S200564. eCollection 2019.
We compared the efficacy of an antiacne hydrogel formulated with a combination of leaf extract, peel extract, and leaf extract (AGC) at a ratio of 50:25:1 with a marketed 1% clindamycin gel (CG) formulation on antiacne and antiblotch activities. A single-center, parallel-arm, randomized controlled trial was performed from November 2017 to April 2018. Sixty subjects with mild-moderate acne severity according to the the American Academy of Dermatology were enrolled for the study. Outcome end points were total acne lesions (TALs) and acne-severity index (ASI) by counting the inflamed lesions and comedones and skin colors using erythema and melanin values. For TALss, a decrease (<0.0001) in the number of total inflamed lesions from baseline was evidenced in AGC group, but not in the CG group. Higher reduction in mean ASI in the AGC group was seen than in the CG group. However, there was no statistically significant difference regarding reduction in ASI between the AGC and CG groups. For erythema, a remarked reduction in skin redness from baseline was clearly seen at day 3 (<0.05) in the AGC group. No significant decrease in erythema values from baseline was seen in the CG group. A significant decrease (=0.037) in mean melanin value from baseline was seen in the AGC group after 14 days of twice-daily use, but not in the CG group. Both products were well tolerated, with no reports of severe adverse events. An anti-acne hydrogel containing a combination of mangosteen rinds, aloe vera gel, and green tea-leaf extracts was superior to 1% clindamycin gel in antiacne and antiblotch activities when measured by TALs and erythema and melanin values.
我们比较了一种由果皮提取物、芦荟凝胶和绿茶叶提取物按50:25:1比例配制的抗痤疮水凝胶（AGC）与市售1%克林霉素凝胶（CG）制剂在抗痤疮和抗色斑活性方面的疗效。2017年11月至2018年4月进行了一项单中心、平行组、随机对照试验。根据美国皮肤病学会标准，招募了60名轻度至中度痤疮严重程度的受试者参与该研究。结局终点为总痤疮皮损（TALs）和痤疮严重指数（ASI），通过计数炎症性皮损和粉刺数量以及使用红斑和黑色素值评估皮肤颜色。对于TALs，AGC组总炎症性皮损数量较基线有减少（<0.0001），而CG组未减少。AGC组平均ASI的降低幅度高于CG组。然而，AGC组和CG组在ASI降低方面无统计学显著差异。对于红斑，AGC组在第3天皮肤发红较基线有明显减少（<0.05）。CG组红斑值较基线无显著降低。AGC组在每日两次使用14天后，平均黑色素值较基线有显著降低（=0.037），而CG组未出现这种情况。两种产品耐受性均良好，无严重不良事件报告。当通过TALs、红斑和黑色素值衡量时，一种含有山竹果皮、芦荟凝胶和绿茶叶提取物组合的抗痤疮水凝胶在抗痤疮和抗色斑活性方面优于1%克林霉素凝胶。
