Gao Yifei, Dai Xujing, Lee Arier C, Wise Michelle R, Shen Fang, Chen Qi
The Hospital of Obstetrics & Gynaecology, Fudan University, China.
Section of Epidemiology and Biostatistics, School of Population Health, The University of Auckland, New Zealand.
J Cancer. 2018 Nov 25;9(24):4756-4761. doi: 10.7150/jca.21137. eCollection 2018.
: Obesity is one of the common risk factors for developing of endometrial cancer and is negatively associated with its survival, although this result is controversial. Endometrial cancer stages range from stage I, which has better clinical outcomes to stage IV, which has poorer clinical outcomes. Endometrial cancer traditionally divides into type 1 and type 2 dependent on histology which has different clinical outcomes. In this study we investigated whether obesity is associated with the stages of endometrial cancer taking into account subtypes of cancer and menopausal status. : Data on 1,104 women with endometrial cancer were retrospectively collected from the largest women's hospital in China and analysed. Data included age at diagnosis, body mass index (BMI), histology of cancer and menopausal status. The BMI in patients with stage I endometrial cancer was significantly higher than that in patients with stage II or III or IV (p=0.0001). However, there was no statistical difference in BMI between patients with stage II, and stage III endometrial cancer. This negative association was persisted with type 1 and type 2 endometrial cancer (p=0.1989) and premenopausal and post-menopausal status (p=0.4342). In addition, the proportion of over-weight or obese women in type1 endometrial cancer with stage I was not different to type 2 endometrial cancer with stage I. Our data demonstrate that BMI is negatively associated with endometrial cancer in early stage regardless of subtypes of cancer, menopausal status and obesity may be also a potential risk factor for developing type 2 endometrial cancer.
肥胖是子宫内膜癌发生的常见危险因素之一，且与子宫内膜癌患者的生存率呈负相关，尽管这一结果存在争议。子宫内膜癌分期从临床结局较好的I期到临床结局较差的IV期。传统上，子宫内膜癌根据组织学分为1型和2型，二者临床结局不同。在本研究中，我们考虑了癌症亚型和绝经状态，调查肥胖是否与子宫内膜癌分期相关。
我们从中国最大的妇产医院回顾性收集并分析了1104例子宫内膜癌女性患者的数据。数据包括诊断时的年龄、体重指数（BMI）、癌症组织学类型和绝经状态。I期子宫内膜癌患者的BMI显著高于II期、III期或IV期患者（p = 0.0001）。然而，II期和III期子宫内膜癌患者的BMI无统计学差异。这种负相关在1型和2型子宫内膜癌（p = 0.1989）以及绝经前和绝经后状态（p = 0.4342）中均持续存在。此外，I期1型子宫内膜癌中超重或肥胖女性的比例与I期2型子宫内膜癌无差异。我们的数据表明，无论癌症亚型和绝经状态如何，BMI与早期子宫内膜癌呈负相关，肥胖也可能是2型子宫内膜癌发生的潜在危险因素。
