Moghadam Reza Heidary, Shahmohammadi Afshar, Asgari Nader, Azizi Koorosh, Mansour Sahar Mehr, Roozbahani Mohammad
Clinical Research Development Center, Imam Ali and Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Blood Res. 2018 Dec;53(4):269-275. doi: 10.5045/br.2018.53.4.269. Epub 2018 Dec 17.
Coronary artery ectasia (CAE) is defined as the dilation of a segment of a coronary vessel to at least 1.5 times the diameter of its normal adjacent segment. Mean platelet volume (MPV) plays a role in acute coronary syndromes, with high MPV correlating to poor prognosis for acute thrombotic events and CAE. Several studies investigated the relationship between MPV and CAE, resulting in conflicting results. These results led us to systematically review all studies investigating the relationship between MPV and ectatic heart diseases by performing a meta-analysis study in order to report a unified result. This meta-analysis study investigated all case-control articles examining the relationship between MPV and CAE. All studies in the following databases published until January 31, 2018, were investigated: Science Direct, Scopus, PubMed, Google Scholar, and Web of Science. Following a quality control evaluation, 14 articles, all of which were published following studies performed in Turkey from 2007 to 2016, met the criteria for study inclusion. After pooling the results from all of the articles, a total standardized mean difference (SMD) value of 0.584 (95% CI, 0.219, 0.95) was obtained using the D+L pooled SMD, indicating a significant difference (=0.002) between the two groups, with higher MPV values in ectatic patients when comparing to healthy individuals. Therefore, increased MPV levels were significantly related to CAE, suggesting that platelets, with their inflammatory and thrombotic activities, play a role in this disease. Therefore, anti-platelet and anti-inflammatory therapies may be effective in treating CAE.
冠状动脉扩张（CAE）被定义为冠状动脉某一段的扩张，其直径至少为相邻正常节段直径的1.5倍。平均血小板体积（MPV）在急性冠状动脉综合征中起作用，高MPV与急性血栓事件和CAE的不良预后相关。多项研究调查了MPV与CAE之间的关系，结果相互矛盾。这些结果促使我们通过进行荟萃分析研究，系统回顾所有调查MPV与扩张性心脏病之间关系的研究，以便报告一个统一的结果。这项荟萃分析研究调查了所有检验MPV与CAE之间关系的病例对照文章。对截至2018年1月31日在以下数据库中发表的所有研究进行了调查：科学Direct、Scopus、PubMed、谷歌学术和科学网。经过质量控制评估，14篇文章符合纳入标准，所有这些文章均发表于2007年至2016年在土耳其进行的研究之后。汇总所有文章的结果后，使用D + L合并标准化均值差（SMD）获得的总标准化均值差（SMD）值为0.584（95%CI，0.219，0.95），表明两组之间存在显著差异（P = 0.002），与健康个体相比，扩张性患者的MPV值更高。因此，MPV水平升高与CAE显著相关，表明具有炎症和血栓形成活性的血小板在这种疾病中起作用。因此，抗血小板和抗炎治疗可能对治疗CAE有效。
