Zhou Li, Lin Shibo, Zhang Fan, Ma Yizhe, Fu Zhenzhen, Gong Yingyun, Hu Dandan, Ma Shuai, Ye Xuan, Qian Leihang, Geng Xiaomei, Yang Ningli, Liang Hui, Zhou Hongwen
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Department of Endocrinology and Metabolism, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
Diabetes Ther. 2020 Oct;11(10):2269-2281. doi: 10.1007/s13300-020-00897-9. Epub 2020 Aug 13.
Red blood cell distribution width (RDW) and mean platelet volume (MPV) are both new biomarkers for the prognosis of many diseases. This study aimed to observe the predictive values of RDW and MPV for weight loss after different metabolic surgeries in patients with obesity and abnormal glucose metabolism [diabetes mellitus or impaired glucose regulation (DM/IGR)].
We retrospectively analyzed the body weight (BW), body mass index (BMI) and blood routine index of 98 patients with obesity and DM/IGR who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG).
Levels of RDW and MPV in both groups were significantly higher than before 1 month after surgery and then gradually decreased. Twelve months after surgery, the RDW level in the RYGB group was significantly lower than that before surgery. In the RYGB group, the RDW level of patients in the high-level percentage weight loss (%BW) (≥ 31.90) at 6 and 12 months after surgery decreased significantly compared to those in the corresponding low level. %BW and change in BW and BMI (ΔBW and ΔBMI) at 6 and 12 months after surgery in the high-level RDW (≥ 12.90) before surgery were significantly higher than those in the low level in the RYGB group. No significant difference in weight index was found in the high and low levels of the MPV before surgery in either group at other follow-up time points.
Preoperative baseline RDW and postoperative RDW levels can preliminarily predict the effect of different metabolic surgeries in patients with obesity and DM/IGR.
红细胞分布宽度（RDW）和平均血小板体积（MPV）均为多种疾病预后的新型生物标志物。本研究旨在观察RDW和MPV对肥胖及糖代谢异常[糖尿病或糖调节受损（DM/IGR）]患者不同代谢手术后体重减轻的预测价值。
我们回顾性分析了98例接受Roux-en-Y胃旁路术（RYGB）或袖状胃切除术（SG）的肥胖及DM/IGR患者的体重（BW）、体重指数（BMI）和血常规指标。
两组患者术后1个月时RDW和MPV水平均显著高于术前，随后逐渐下降。术后12个月时，RYGB组的RDW水平显著低于术前。在RYGB组中，术后6个月和12个月时体重减轻百分比（%BW）处于高水平（≥31.90）的患者的RDW水平相较于相应低水平患者显著降低。术前RDW高水平（≥12.90）的患者术后6个月和12个月时的%BW以及BW和BMI的变化（ΔBW和ΔBMI）显著高于RYGB组中的低水平患者。在其他随访时间点，两组术前MPV高水平和低水平患者的体重指数均无显著差异。
术前基线RDW和术后RDW水平可初步预测肥胖及DM/IGR患者不同代谢手术的效果。
