Demir Mehmet, Demir Canan, Keceoglu Serdar
Bursa Yuksek Ihtisas Education and Research Hospital Cardiology Department, Bursa, Turkey.
Bursa Sevket Yilmaz Education and Research Hospital Infectious Disease Department, Bursa, Turkey.
Cardiol Res. 2014 Oct;5(5):151-154. doi: 10.14740/cr315w. Epub 2014 Oct 6.
The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that monocytes play an important role in inflammation, atherosclerosis and cardiovascular disease. We aimed to compare the numbers of monocyte counts of the CAE patients versus controls.
This study included 84 CAE patients (40 male, mean age 55.4 ± 9.7 years) and 30 controls (10 male, mean age 57.86 ± 11.6 years). Concurrent routine biochemical tests and neutrophil, lymphocyte, monocyte count and mean platelet volume (MPV) on whole blood count were performed for these participants. These parameters were compared between groups.
Baseline characteristics of the study groups were comparable. CAE patients had a higher MPV value and monocyte count than controls (8.8 ± 0.2 vs. 6.2 ± 1.6 fL and 732 ± 88 vs. 321 ± 75 cell/μL; both P < 0.001, respectively).
As a result, our study revealed a relationship between monocyte count and MPV in patients with CAE.
尽管已有包括动脉炎、内皮功能障碍和动脉粥样硬化血栓形成在内的多种异常情况的报道，但冠状动脉扩张（CAE）的病理生理学尚未明确。已知单核细胞在炎症、动脉粥样硬化和心血管疾病中起重要作用。我们旨在比较CAE患者与对照组的单核细胞计数。
本研究纳入84例CAE患者（40例男性，平均年龄55.4±9.7岁）和30例对照组（10例男性，平均年龄57.86±11.6岁）。对这些参与者同时进行常规生化检查以及全血细胞计数中的中性粒细胞、淋巴细胞、单核细胞计数和平均血小板体积（MPV）检测。对这些参数进行组间比较。
研究组的基线特征具有可比性。CAE患者的MPV值和单核细胞计数高于对照组（分别为8.8±0.2对6.2±1.6 fL以及732±88对321±75细胞/μL；均P<0.001）。
因此，我们的研究揭示了CAE患者单核细胞计数与MPV之间的关系。
